Department of Internal Medicine, Pedro Hispano Hospital, Matosinhos Local Health Unit. Matosinhos, Portugal.
Anatomic Pathology Service, Pedro Hispano Hospital, Matosinhos Local Health Unit. Matosinhos, Portugal.
Eur J Intern Med. 2021 Dec;94:69-72. doi: 10.1016/j.ejim.2021.07.012. Epub 2021 Aug 9.
The minor salivary glands' biopsy is a minimally invasive procedure used for the diagnosis of Sjögren's syndrome. Its significance has also been reported in other inflammatory/infiltrative diseases. The objectives are to investigate its use in the diagnosis of Sjögren's syndrome, as well as to evaluate its role in the diagnosis of amyloidosis and sarcoidosis.
A retrospective analysis was carried out on patients who underwent minor salivary glands' biopsies between April of 2014 and December of 2017.
A total of 173 patients were identified. Of the patients with suspected Sjögren's syndrome, in 40% of the cases there was evidence of lymphocytic sialadenitis. The antibodies against SSA, antinuclear antibodies and the Rheumatoid Factor correlated significantly with the presence of lymphocytic sialadenitis. The result of the minor salivary glands' biopsies allowed an increase of 12.4% of patients who met the criteria defined by the American - European Consensus Group. Of the patients with suspected amyloidosis (25%), the biopsies were positive in 4 patients.
The minor salivary glands' biopsy is a simple procedure with effectiveness in the diagnosis of Sjögren's syndrome and amyloidosis. In this study, its use increased the number of patients who met the Sjögren's syndrome classification criteria. It also appears to be useful in the diagnosis of amyloidosis.
唾液腺活检是一种微创程序，用于诊断干燥综合征。它在其他炎症/浸润性疾病中的意义也有报道。目的是研究其在干燥综合征诊断中的应用，并评估其在淀粉样变性和结节病诊断中的作用。
对 2014 年 4 月至 2017 年 12 月期间进行唾液腺活检的患者进行回顾性分析。
共确定了 173 名患者。在疑似干燥综合征的患者中，40%的患者有淋巴细胞性唾液腺炎的证据。抗 SSA、抗核抗体和类风湿因子与淋巴细胞性唾液腺炎的存在显著相关。唾液腺活检的结果使符合美国-欧洲共识组定义标准的患者增加了 12.4%。在疑似淀粉样变性的患者（25%）中，有 4 例活检阳性。
唾液腺活检是一种简单的程序，可有效诊断干燥综合征和淀粉样变性。在这项研究中，它的使用增加了符合干燥综合征分类标准的患者数量。它似乎也有助于诊断淀粉样变性。
