Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Open Heart. 2021 Aug;8(2). doi: 10.1136/openhrt-2021-001674.
Periodontitis has been independently associated to cardiovascular disease. However, the biological mechanisms underlying such association are still partially unknown. Thus, this study aimed to discover immunological clues accounting for the increased risk of myocardial infarction (MI) in patients having periodontitis.
We included 100 patients with a first MI, 50 with and 50 without severe periodontitis, and 100 age-matched, sex-matched and area-matched controls from the Periodontitis and Its Relation to Coronary Artery Disease Study. Participants underwent comprehensive clinical and laboratory examinations 6-10 weeks after the MI and plasma expression of 92 inflammation-related markers was assessed through proximity extension assay.
Patients who had an MI displayed altered expression of CCL19, TNFRSF9 and LAP TGF-β1 in comparison with controls. TNFRSF9 correlated significantly with the amount of alveolar bone loss. MI patients with deep periodontal pockets showed increased white cell count and higher expression of FGF-21, HGF, OSM, CCL20 and IL-18R1 than patients without. White cell count correlated significantly with four of these proteins.
Collectively, our results indicate molecular markers that could be responsible for the increased systemic inflammatory activity in patients with MI with periodontitis.
牙周炎与心血管疾病独立相关。然而，这种关联的生物学机制仍不完全清楚。因此，本研究旨在发现解释牙周炎患者心肌梗死（MI）风险增加的免疫学线索。
我们纳入了来自牙周炎及其与冠状动脉疾病关系研究的 100 名首次发生 MI 的患者、50 名伴严重牙周炎的患者和 50 名无严重牙周炎的患者，以及 100 名年龄、性别和地区匹配的对照者。参与者在 MI 后 6-10 周接受了全面的临床和实验室检查，并通过接近延伸测定法评估了 92 种炎症相关标志物的血浆表达。
与对照组相比，发生 MI 的患者 CCL19、TNFRSF9 和 LAP TGF-β1 的表达发生改变。TNFRSF9 与牙槽骨丧失量显著相关。深牙周袋的 MI 患者的白细胞计数增加，FGF-21、HGF、OSM、CCL20 和 IL-18R1 的表达水平更高，与不伴深牙周袋的 MI 患者相比。白细胞计数与其中 4 种蛋白显著相关。
综上所述，我们的研究结果表明，这些分子标志物可能是牙周炎伴 MI 患者全身性炎症活性增加的原因。
