二硫代氨基甲酸盐对镉诱导的精子乙酰转移酶变化的抑制作用。

Dithiocarbamate inhibition of cadmium-induced changes in spermatozoan acetyltransferases.

作者信息

Dwivedi C, Kumar S S, Walker E M, Jones S G, Jones M M

机构信息

Department of Medical Genetics, Meharry Medical College, Nashville, Tennessee 37208.

出版信息

Res Commun Chem Pathol Pharmacol. 1987 Dec;58(3):355-70.

PMID:3438571

Abstract

The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) subsequent to the administration of CdCl2.2.5H2O to male rats, inhibits the cadmium-induced decreases in spermatozoan acetyltransferase (AT) levels and provides marked protection against the cadmium-induced morphologic testicular changes in the cauda and corpus and partial protection against the changes in the caput.

摘要

给雄性大鼠注射二水合氯化镉（CdCl₂·2.5H₂O）后再注射N-甲基-N-二硫代羧基-D-葡糖胺钠（NaG），可抑制镉诱导的精子乙酰转移酶（AT）水平降低，并显著保护睾丸尾部和体部免受镉诱导的形态学变化影响，对头部变化有部分保护作用。