二硫代氨基甲酸盐类似物N-(4-甲氧基苄基)-N-二硫代羧基-D-葡糖胺可降低大鼠体内摄入镉的潴留。

Dithiocarbamate analog N-(4-methoxybenzyl)-N-dithiocarboxy-D-glucamine reduces the retention of ingested cadmium in rats.

作者信息

Kargacin B, Kostial K, Arezina R, Singh P K, Jones M M, Cikrt M

机构信息

Department of Mineral Metabolism, University of Zagreb, Yugoslavia.

出版信息

J Appl Toxicol. 1991 Oct;11(5):313-5. doi: 10.1002/jat.2550110503.

DOI:10.1002/jat.2550110503

PMID:1783734

Abstract

This study was performed to evaluate the effect of oral and intraperitoneal treatment with N-(4-methoxybenzyl)-D-glucamine dithiocarbamate monohydrate (MeOBDCG) after a single oral administration of 115mCd to 6-week-old rats. Oral treatment reduced the retention of 115mCd in the whole body, gut, liver and kidney by 5, 3, 4 and 3 times respectively, and intraperitoneal treatment reduced the retention by 7, 2.5, 16 and 4.5 times, respectively. This finding is new, since it was believed that oral dithiocarbamate treatment would increase the toxicity and absorption of ingested cadmium.

摘要

本研究旨在评估6周龄大鼠单次口服115mCd后，口服及腹腔注射N-(4-甲氧基苄基)-D-氨基葡萄糖二硫代氨基甲酸盐一水合物（MeOBDCG）的效果。口服治疗分别使全身、肠道、肝脏和肾脏中115mCd的滞留量降低了5倍、3倍、4倍和3倍，腹腔注射治疗分别使滞留量降低了7倍、2.5倍、16倍和4.5倍。这一发现是全新的，因为此前人们认为口服二硫代氨基甲酸盐治疗会增加摄入镉的毒性和吸收。