食欲抑制剂对荷Walker-256肿瘤大鼠的影响。
Effects of anorectic agents in rats bearing the Walker-256 tumor.
作者信息
Maickel R P, Johnson K, Kinney D R
机构信息
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
出版信息
Res Commun Chem Pathol Pharmacol. 1987 Dec;58(3):421-4.
Since changes of levels of biogenic amines have been found in some brain areas of rats bearing the Walker-256 tumor, a study was performed to assess the actions of three anorectic agents in such animals. The results obtained by dosage of d-amphetamine, fenfluramine or mazindol, on days 5 and 8 after tumor implantation, failed to demonstrate conclusively any predominant modification of a dopaminergic, noradrenergic, or serotonergic system in the anorectic effects of these agents.
由于在携带Walker-256肿瘤的大鼠的某些脑区中发现了生物胺水平的变化，因此进行了一项研究，以评估三种厌食剂在此类动物中的作用。在肿瘤植入后第5天和第8天，通过给予右旋苯丙胺、芬氟拉明或马吲哚所获得的结果，未能确凿地证明这些药剂的厌食作用中多巴胺能、去甲肾上腺素能或5-羟色胺能系统有任何主要改变。
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