Opitz K
Int J Obes. 1978;2(1):59-68.
Rats were treated chronically with various anorexigenic substances which were administered orally once (or twice) daily or bidaily. Complete tolerance to the anorectic effect of d-amphetamine, fenfluramine, benfluorex (780 SE), chlorphentermine, and mazindol developed in 11-17 days. Test doses were given at different points of time after withdrawal in order to recognize the presence or absence of direct or cross tolerance. Direct tolerance to fenfluramine and benfluorex persisted for 46 days, whereas tolerance to mazindol was no longer present at day 20. There was lasting bidirectional cross tolerance between chlorphentermine and fenfluramine, transient bidirectional cross tolerance between mazindol and amphetamine, but only unidirectional cross tolerance between amphetamine and fenfluramine.
大鼠长期接受各种食欲抑制物质的处理，这些物质每天口服一次（或两次）或隔天服用一次。对右旋苯丙胺、芬氟拉明、苄氟雷司（780 SE）、氯苯丁胺和马吲哚的厌食作用在11 - 17天内产生了完全耐受性。在撤药后的不同时间点给予测试剂量，以识别直接耐受性或交叉耐受性的存在与否。对芬氟拉明和苄氟雷司的直接耐受性持续了46天，而对马吲哚的耐受性在第20天时已不复存在。氯苯丁胺和芬氟拉明之间存在持久的双向交叉耐受性，马吲哚和苯丙胺之间存在短暂的双向交叉耐受性，但苯丙胺和芬氟拉明之间仅存在单向交叉耐受性。
