Zhang Yao, Chen Yu, Wan Yue, Zhao Yueshui, Wen Qinglian, Tang Xiaolong, Shen Jing, Wu Xu, Li Mingxing, Li Xiang, Li Jing, Li Wanping, Xiao Zhangang, Du Fukuan
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
South Sichuan Institute of Translational Medicine, Luzhou, China.
Front Pharmacol. 2021 Jul 27;12:697903. doi: 10.3389/fphar.2021.697903. eCollection 2021.
Oxidative stress caused by an imbalance between the production and elimination of reactive metabolites and free radicals can lead to the development of a variety of diseases. Over the past years, with the development of science and technology, circular RNA (circRNA) has been found to be closely associated with oxidative stress, which plays an important role in the process of oxidative stress. Currently, the understanding of circRNAs in the mechanism of oxidative stress is limited. In this review, we described the relationship between oxidative stress and circRNAs, the circRNAs related to oxidative stress, and the role of circRNAs in promoting or inhibiting the occurrence and development of diseases associated with the oxidative stress system.
活性代谢产物和自由基的产生与消除之间的失衡所导致的氧化应激,可引发多种疾病。在过去几年中,随着科学技术的发展,人们发现环状RNA(circRNA)与氧化应激密切相关,其在氧化应激过程中发挥着重要作用。目前,对于circRNA在氧化应激机制方面的认识仍较为有限。在本综述中,我们阐述了氧化应激与circRNA之间的关系、与氧化应激相关的circRNA,以及circRNA在促进或抑制与氧化应激系统相关疾病的发生和发展中所起的作用。