Jin Hengyu, Liu Jianxin, Wang Diming
Institute of Dairy Science, MoE Key Laboratory of Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Antioxidants (Basel). 2024 Aug 8;13(8):964. doi: 10.3390/antiox13080964.
This review delves into the advantages of exosomes as novel antioxidants in animal nutrition and their potential for regulating oxidative stress. Although traditional nutritional approaches promote oxidative stress defense systems in mammalian animals, several issues remain to be solved, such as low bioavailability, targeted tissue efficiency, and high-dose by-effect. As an important candidate offering regulation opportunities concerned with cellular communication, disease prevention, and physiology regulation in multiple biological systems, the potential of exosomes in mediating redox status in biological systems has not been well described. A previously reported relationship between redox system regulation and circulating exosomes suggested exosomes as a fundamental candidate for both a regulator and biomarker for a redox system. Herein, we review the effects of oxidative stress on exosomes in animals and the potential application of exosomes as antioxidants in animal nutrition. Then, we highlight the advantages of exosomes as redox regulators due to their higher bioavailability and physiological heterogeneity-targeted properties, providing a theoretical foundation and feed industry application. Therefore, exosomes have shown great potential as novel antioxidants in the field of animal nutrition. They can overcome the limitations of traditional antioxidants in terms of dosage and side effects, which will provide unprecedented opportunities in nutritional management and disease prevention, and may become a major breakthrough in the field of animal nutrition.
本综述深入探讨了外泌体作为动物营养中新型抗氧化剂的优势及其调节氧化应激的潜力。尽管传统营养方法可促进哺乳动物的氧化应激防御系统，但仍有几个问题有待解决，如生物利用度低、靶向组织效率以及高剂量副作用等。作为在多个生物系统中提供与细胞通讯、疾病预防和生理调节相关调节机会的重要候选者，外泌体在生物系统中介导氧化还原状态的潜力尚未得到充分描述。先前报道的氧化还原系统调节与循环外泌体之间的关系表明，外泌体是氧化还原系统调节剂和生物标志物的基本候选者。在此，我们综述了氧化应激对动物外泌体的影响以及外泌体作为抗氧化剂在动物营养中的潜在应用。然后，我们强调了外泌体作为氧化还原调节剂的优势，因其具有更高的生物利用度和针对生理异质性的特性，为饲料工业应用提供了理论基础。因此，外泌体在动物营养领域已显示出作为新型抗氧化剂的巨大潜力。它们可以克服传统抗氧化剂在剂量和副作用方面的局限性，这将在营养管理和疾病预防方面提供前所未有的机会，并可能成为动物营养领域的一项重大突破。
