Department of Neurology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The Fourth Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, China.
Oxid Med Cell Longev. 2021 Mar 1;2021:6659908. doi: 10.1155/2021/6659908. eCollection 2021.
Circular RNAs (circRNAs) are novel noncoding RNAs that play regulatory roles in gene expression. Dysregulation of circRNAs is associated with the development and progression of several diseases, such as diabetes mellitus, nervous system diseases, cardiovascular diseases, and cancer. CircRNAs functionally participate in cell physiological activities through various molecular mechanisms. However, these molecular mechanisms are unclear. Oxidative stress is an essential factor in the pathogenesis of various diseases, including neurological diseases. Emerging roles of circRNAs have been identified in different systems in response to oxidative stress. In this review, we summarize the current understanding of circRNA biogenesis, properties, expression profiles, and the clues indicating the regulatory roles of circRNAs through oxidative stress in various systems, especially the nervous system.
环状 RNA（circRNAs）是一类新型的非编码 RNA，在基因表达调控中发挥作用。circRNAs 的失调与多种疾病的发生和发展有关，如糖尿病、神经系统疾病、心血管疾病和癌症。circRNAs 通过多种分子机制参与细胞生理活动。然而，这些分子机制尚不清楚。氧化应激是包括神经疾病在内的多种疾病发病机制中的一个重要因素。circRNAs 在不同系统中对氧化应激的反应中的作用也逐渐被揭示。在这篇综述中，我们总结了目前对 circRNA 生物发生、特性、表达谱的认识，以及提示 circRNAs 通过氧化应激在不同系统（特别是神经系统）中发挥调控作用的线索。
