Moser Monika, Radu Iuliana-Pompilia, Dufour Jean-François
Hepatology, Department of Clinical Research University of Bern Bern Switzerland.
University Clinic for Visceral Surgery and Medicine, Inselspital Bern Switzerland.
JGH Open. 2021 Jul 6;5(8):864-870. doi: 10.1002/jgh3.12533. eCollection 2021 Aug.
BACKGROUND AND AIM: Treatment with sorafenib causes diverse side effects, which limits adherence. This work assesses whether Home Care, a psychosocial nursing intervention, prolongs the duration of treatment in patients with advanced hepatocellular carcinoma (HCC) and if it influences health-related quality of life (HRQL). METHODS AND RESULTS: This is a cohort study using data from patients receiving sorafenib in the prospective Bern HCC Cohort at the University Hospital. Duration of treatment, overall survival, and HRQL using the Functional Assessment of Cancer Therapy-Hepatobiliary questionnaire were compared in the two groups. A total of 173 patients were eligible for the analysis. Among them, 141 were in the Home Care program, and 32 were not. Patients with Home Care had a significantly longer duration of treatment (265 days 152 days, = 0.003) and a better functional well-being (17.7 12.5, = 0.015). CONCLUSION: Psychosocial interventions such as Home Care are a valid method in improving adherence to sorafenib and can therefore be recommended.
背景与目的：索拉非尼治疗会引发多种副作用，这限制了患者的依从性。本研究评估心理社会护理干预措施“家庭护理”是否能延长晚期肝细胞癌（HCC）患者的治疗时长，以及是否会影响其健康相关生活质量（HRQL）。 方法与结果：这是一项队列研究，使用了大学医院前瞻性伯尔尼HCC队列中接受索拉非尼治疗患者的数据。比较了两组患者的治疗时长、总生存期以及使用癌症治疗功能评估-肝胆问卷得出的HRQL。共有173例患者符合分析条件。其中，141例参与了家庭护理项目，32例未参与。接受家庭护理的患者治疗时长显著更长（265天对152天，P = 0.003），且健康状况良好程度更高（17.7对12.5，P = 0.015）。 结论：诸如家庭护理这样的心理社会干预措施是提高索拉非尼依从性的有效方法，因此值得推荐。
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