Ruđer Bošković Institute, Zagreb, Croatia.
Prog Mol Subcell Biol. 2021;60:57-83. doi: 10.1007/978-3-030-74889-0_3.
Noncoding DNA sequences repeated in tandem or satellite DNAs make an integral part of every eukaryotic genome. Development and application of new methodological approaches through time enabled gradual improvement in understanding of structural and functional roles of these sequences, early misconsidered as "junk DNA". Advancing approaches started adding novel insights into details of their existence on the genomic scale, traditionally hard to access due to difficulties in analyzing long arrays of nearly identical tandem repeats of a satellite DNA. In turn, broadened views opened space for the development of new concepts on satellite DNA biology, highlighting also specificities coming from different groups of organisms. Observed diversities in different aspects and in organizational forms of these sequences proclaimed a need for a versatile pool of model organisms. Peculiarities of satellite DNAs populating genomes of bivalve mollusks, an important group of marine and fresh-water organisms, add to the diversity of organizational principles and associated roles in which tandemly repeated sequences contribute to the genomes.
非编码 DNA 序列串联重复或卫星 DNA 是每个真核基因组的重要组成部分。随着时间的推移,新方法的不断发展和应用,逐渐提高了我们对这些序列结构和功能作用的理解,这些序列曾被早期错误地认为是“垃圾 DNA”。新方法的发展开始深入了解它们在基因组尺度上的存在细节,由于分析卫星 DNA 中几乎相同的串联重复长序列存在困难,这些细节在传统上很难获得。反过来,更广泛的观点为卫星 DNA 生物学的新概念的发展提供了空间,也突出了来自不同生物群体的特异性。这些序列在不同方面和组织形式上的多样性宣告了需要一个多功能的模式生物群体。在双壳类软体动物基因组中存在的卫星 DNA 的特殊性增加了组织原则的多样性,并在其中串联重复序列为基因组做出贡献的相关作用中增加了多样性。