新生儿癫痫的新疗法。
Novel Therapeutics for Neonatal Seizures.
机构信息
Department of Pediatrics, Michigan Medicine, C.S. Mott Children's Hospital, University of Michigan, 1540 E. Hospital Dr, Ann Arbor, MI, USA.
Department of Pediatrics, Section of Neurology, Denver Anschutz School of Medicine, Children's Hospital Colorado, University of Colorado, Aurora, CO, 80045, USA.
出版信息
Neurotherapeutics. 2021 Jul;18(3):1564-1581. doi: 10.1007/s13311-021-01085-8. Epub 2021 Aug 12.
Abstract
Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present emerging therapies in clinical and preclinical development for the treatment of acute symptomatic neonatal seizures. Lastly, we discuss the role of precision therapies for genetic neonatal-onset epilepsies and address barriers and goals for developing new therapies for clinical care.
摘要
新生儿癫痫发作是一种常见的神经系统急症，几十年来其治疗方法并没有显著改变。急性症状性癫痫发作和新生儿起病癫痫的诊断和病理生理学理解的改善为开发具有改善预后潜力的精准治疗方法提供了极好的机会。在此，我们讨论新生儿癫痫发作的病理生理学，并回顾现有治疗方法的证据。我们介绍了正在临床和临床前开发的用于治疗急性症状性新生儿癫痫发作的新兴疗法。最后，我们讨论了精准疗法在遗传性新生儿起病癫痫中的作用，并探讨了为临床治疗开发新疗法的障碍和目标。
相似文献
1
Novel Therapeutics for Neonatal Seizures.新生儿癫痫的新疗法。
Neurotherapeutics. 2021 Jul;18(3):1564-1581. doi: 10.1007/s13311-021-01085-8. Epub 2021 Aug 12.
2
Summary proceedings from the neurology group on neonatal seizures.神经病学小组关于新生儿惊厥的简易程序。
Pediatrics. 2006 Mar;117(3 Pt 2):S23-7. doi: 10.1542/peds.2005-0620D.
3
Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy.实施神经重症监护计划：改善缺氧缺血性脑病新生儿出院时的癫痫检测并减少抗癫痫药物使用
Pediatr Neurol. 2016 Nov;64:38-43. doi: 10.1016/j.pediatrneurol.2016.07.007. Epub 2016 Aug 3.
4
Neonatal seizures: after all these years we still love what doesn't work.新生儿惊厥：这么多年过去了，我们仍然热衷于那些无效的方法。
Neurology. 2005 Mar 8;64(5):776-7. doi: 10.1212/01.WNL.0000157320.78071.6D.
5
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.布美他尼治疗新生儿惊厥的一项随机、对照、双盲试验。
Ann Neurol. 2021 Feb;89(2):327-340. doi: 10.1002/ana.25959. Epub 2020 Dec 3.
6
Levetiracetam for the treatment of neonatal seizures.左乙拉西坦用于治疗新生儿惊厥。
J Child Neurol. 2007 Jan;22(1):95-8. doi: 10.1177/0883073807299973.
7
Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy.左乙拉西坦用于治疗新生儿缺氧缺血性脑病的癫痫发作
J Child Neurol. 2017 Feb;32(2):210-214. doi: 10.1177/0883073816678102. Epub 2016 Nov 22.
8
Midazolam in neonatal seizures with no response to phenobarbital.咪达唑仑用于对苯巴比妥无反应的新生儿惊厥。
Neurology. 2005 Mar 8;64(5):876-9. doi: 10.1212/01.WNL.0000152891.58694.71.
9
Why we urgently need improved seizure and epilepsy therapies for children and neonates.为什么我们急需为儿童和新生儿改进癫痫发作和癫痫治疗方法。
Neuropharmacology. 2020 Jun 15;170:107854. doi: 10.1016/j.neuropharm.2019.107854. Epub 2019 Nov 18.
10
Response to antiseizure medications in neonates with acute symptomatic seizures.新生儿急性症状性癫痫发作时抗癫痫药物的反应。
Epilepsia. 2019 Mar;60(3):e20-e24. doi: 10.1111/epi.14671. Epub 2019 Feb 20.
引用本文的文献
1
Neonatal Non-metabolic Seizure Distribution in Relation to Biochemical Abnormalities.新生儿非代谢性癫痫发作分布与生化异常的关系
Cureus. 2025 Feb 26;17(2):e79723. doi: 10.7759/cureus.79723. eCollection 2025 Feb.
2
Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy.治疗缺氧缺血性脑病新生儿的癫痫发作和改善其结局。
Clin Perinatol. 2024 Sep;51(3):573-586. doi: 10.1016/j.clp.2024.04.013. Epub 2024 May 22.
3
Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.危重新生儿常用抗生素、镇痛镇静药及抗惊厥药：一项叙述性综述
Children (Basel). 2024 Jul 18;11(7):871. doi: 10.3390/children11070871.
4
A Review of the Association between Infections, Seizures, and Drugs.感染、癫痫发作与药物之间关联的综述
Cent Nerv Syst Agents Med Chem. 2025;25(1):49-55. doi: 10.2174/0118715249288932240416071636.
5
Questions and Controversies in Neonatal Seizures.新生儿惊厥的问题与争议
Children (Basel). 2023 Dec 29;11(1):40. doi: 10.3390/children11010040.
6
Genetic Background of Epilepsy and Antiepileptic Treatments.癫痫的遗传背景和抗癫痫治疗。
Int J Mol Sci. 2023 Nov 14;24(22):16280. doi: 10.3390/ijms242216280.
7
Efficacy and safety of ketamine for neonatal refractory status epilepticus: case report and systematic review.氯胺酮治疗新生儿难治性癫痫持续状态的疗效和安全性：病例报告及系统评价
Front Pediatr. 2023 Jun 2;11:1189478. doi: 10.3389/fped.2023.1189478. eCollection 2023.
8
Ionic Plasticity: Common Mechanistic Underpinnings of Pathology in Spinal Cord Injury and the Brain.离子塑性：脊髓损伤和大脑病理的共同机制基础。
Cells. 2022 Sep 17;11(18):2910. doi: 10.3390/cells11182910.
9
Precision Treatments in Epilepsy.癫痫的精准治疗
Neurotherapeutics. 2021 Jul;18(3):1429-1431. doi: 10.1007/s13311-021-01147-x. Epub 2021 Oct 26.
本文引用的文献
1
Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs.新生猕猴短期和长期暴露于抗惊厥药物后引起的脑病理变化。
Neurobiol Dis. 2021 Feb;149:105245. doi: 10.1016/j.nbd.2020.105245. Epub 2020 Dec 29.
2
Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system.电子健康记录通用数据元素在儿科癫痫中的设计与实现：迈向学习型医疗保健系统的基础。
Epilepsia. 2021 Jan;62(1):198-216. doi: 10.1111/epi.16733. Epub 2020 Dec 24.
3
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.苯巴比妥和咪达唑仑可抑制新生鼠窒息模型的癫痫发作，而布美他尼无效。
Epilepsia. 2021 Apr;62(4):920-934. doi: 10.1111/epi.16778. Epub 2020 Dec 1.
4
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.布美他尼治疗新生儿惊厥的一项随机、对照、双盲试验。
Ann Neurol. 2021 Feb;89(2):327-340. doi: 10.1002/ana.25959. Epub 2020 Dec 3.
5
Evaluation of Two Fosphenytoin Loading Dose Regimens and Monitoring in Infants and Neonates Less Than Six Months of Age.两种磷苯妥英负荷剂量方案的评估及小于6月龄婴儿和新生儿的监测
J Pediatr Pharmacol Ther. 2020;25(7):617-622. doi: 10.5863/1551-6776-25.7.617.
6
Genetic Etiologies of Neonatal Seizures.新生儿癫痫的遗传病因学。
Neoreviews. 2020 Oct;21(10):e663-e672. doi: 10.1542/neo.21-10-e663.
7
Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital.苯妥英钠对比苯巴比妥作为新生儿癫痫一线抗癫痫药物的疗效。
J Child Neurol. 2021 Jan;36(1):30-37. doi: 10.1177/0883073820947514. Epub 2020 Aug 19.
8
Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex?婴儿结节性硬化症伴发的癫痫是否会导致自闭症？
Ann Clin Transl Neurol. 2020 Aug;7(8):1371-1381. doi: 10.1002/acn3.51128. Epub 2020 Jul 23.
9
2-Deoxyglucose terminates pilocarpine-induced status epilepticus in neonatal rats.2-脱氧葡萄糖可终止新生大鼠匹罗卡品诱导的癫痫持续状态。
Epilepsia. 2020 Jul;61(7):1528-1537. doi: 10.1111/epi.16583. Epub 2020 Jun 19.
10
Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.左乙拉西坦和苯巴比妥单药治疗新生儿临床惊厥对足月儿神经认知结局的比较。
Seizure. 2020 Aug;80:71-74. doi: 10.1016/j.seizure.2020.06.006. Epub 2020 Jun 5.
Zotero 插件