Department of Pediatrics, Michigan Medicine, C.S. Mott Children's Hospital, University of Michigan, 1540 E. Hospital Dr, Ann Arbor, MI, USA.
Department of Pediatrics, Section of Neurology, Denver Anschutz School of Medicine, Children's Hospital Colorado, University of Colorado, Aurora, CO, 80045, USA.
Neurotherapeutics. 2021 Jul;18(3):1564-1581. doi: 10.1007/s13311-021-01085-8. Epub 2021 Aug 12.
Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present emerging therapies in clinical and preclinical development for the treatment of acute symptomatic neonatal seizures. Lastly, we discuss the role of precision therapies for genetic neonatal-onset epilepsies and address barriers and goals for developing new therapies for clinical care.
新生儿癫痫发作是一种常见的神经系统急症,几十年来其治疗方法并没有显著改变。急性症状性癫痫发作和新生儿起病癫痫的诊断和病理生理学理解的改善为开发具有改善预后潜力的精准治疗方法提供了极好的机会。在此,我们讨论新生儿癫痫发作的病理生理学,并回顾现有治疗方法的证据。我们介绍了正在临床和临床前开发的用于治疗急性症状性新生儿癫痫发作的新兴疗法。最后,我们讨论了精准疗法在遗传性新生儿起病癫痫中的作用,并探讨了为临床治疗开发新疗法的障碍和目标。