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阿片类药物使用障碍:美国青少年中被忽视的人类免疫缺陷病毒风险。

Opioid use disorder: a neglected human immunodeficiency virus risk in American adolescents.

机构信息

Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham.

Division of Adolescent Medicine, University of Alabama at Birmingham.

出版信息

AIDS. 2021 Nov 15;35(14):2237-2247. doi: 10.1097/QAD.0000000000003051.

Abstract

In 2017 alone, 783 000 children aged 12-17 years misused opioids with 14 000 using heroin. Opioid misuse and opioid use disorder (OUD) in adolescents and young adults are significant barriers to ending the HIV epidemic. To address these synergistic scourges requires dedicated practitioners and improved access to life-saving evidence-based treatment. Adolescents and young adults make up over one in five new HIV diagnoses even though they are less likely to be tested or know they are infected. Adolescents and young adults living with HIV are less likely to be retained in care or achieve virological suppression. OUD further leads to increased rates of risky behaviours (like sex without condoms), deceased retention in HIV care and decreased rates of viral suppression in this vulnerable population. Medications for opioid use disorder (MOUD) are recommended for adolescents and young adults with severe OUD and help retain youth in HIV treatment and decrease risk of death. However, due to stigma and lack of experience prescribing MOUD in adolescents, MOUD is often perceived as a last line option. MOUD remains difficult to access for adolescents with a shortage of providers and decreased options for treatment as compared to adults. Addiction treatment is infection prevention, and integrated addiction and HIV services are recommended to improve health outcomes. A multipronged approach including patient education, provider training and policy changes to improve access to treatment and harm reduction are urgently needed confront the drug use epidemic in youth.

摘要

仅在 2017 年,就有 783000 名 12-17 岁的儿童滥用阿片类药物,其中 14000 人使用海洛因。青少年和年轻人中阿片类药物滥用和阿片类药物使用障碍(OUD)是终结艾滋病毒流行的重大障碍。要解决这些协同的祸害,需要有专门的从业者,并改善获得救命的循证治疗的机会。尽管青少年接受检测或知晓自己感染的可能性较低,但他们仍占新诊断出的艾滋病毒病例的五分之一以上。感染艾滋病毒的青少年和年轻人更不可能留在护理中,也更不可能实现病毒学抑制。OUD 进一步导致危险行为(如无保护性行为)的发生率增加,艾滋病毒护理的保留率降低,以及该脆弱人群中病毒抑制率降低。对于患有严重 OUD 的青少年和年轻人,建议使用阿片类药物使用障碍治疗药物(MOUD),以帮助他们留在艾滋病毒治疗中,并降低死亡风险。然而,由于耻辱感和在青少年中开处 MOUD 的经验不足,MOUD 通常被视为最后一线选择。与成年人相比,青少年获得 MOUD 的机会较少,提供治疗的选择也较少。戒毒治疗就是预防感染,建议提供综合性的戒毒和艾滋病毒服务,以改善健康结果。需要采取多管齐下的方法,包括患者教育、提供者培训和政策改革,以改善获得治疗和减少伤害的机会,从而紧急应对青年吸毒流行问题。

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