Suppr超能文献

3D 打印技术在药物制剂开发中的最新进展。

Recent update of 3D printing technology in pharmaceutical formulation development.

机构信息

Department of Pharmaceutics, Delhi Pharmaceutical Science and Research University, Delhi, India.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India.

出版信息

J Biomater Sci Polym Ed. 2021 Dec;32(17):2306-2330. doi: 10.1080/09205063.2021.1967702. Epub 2021 Aug 26.

Abstract

In modern world, Pharma sector observes steep increase in demand of personalized medicine. Various unique ideas and technology were proposed and implemented by different researchers to prepare personalized medicine and devices. 3-dimensional printing (3DP) is one of the revolutionary technologies which can be used to prepare tailored medicine CAD (Computer Aided Design) software. 3DP allows researchers to manufacture customized dosage form with desired modifications in geometry which would in turn alter dosage behaviour of the product with reduced side effects. Current achievement of 3DP includes personalized and adjustable dosage form, multifunction drug delivery systems, medical devices, phantoms, and implants specific to patient anatomy. Additionally, 3DP is employed for preparing tailored regenerative medicines. This review focuses on 3DP use in pharmaceuticals including drug delivery systems and medical devices with their method of fabrication. Additionally, different clinical trials as well as different patents done till date are cited in the paper. Furthermore, regulatory issues and future perspective related to 3 D printing is also well discussed.

摘要

在现代世界,制药行业观察到个性化药物的需求急剧增加。不同的研究人员提出并实施了各种独特的想法和技术来制备个性化药物和设备。3 维打印(3DP)是一种革命性的技术,可用于制备定制药物 CAD(计算机辅助设计)软件。3DP 允许研究人员制造具有所需几何形状修改的定制剂型,这反过来又会改变产品的剂量行为,减少副作用。3DP 的当前成果包括个性化和可调节的剂型、多功能药物输送系统、医疗器械、患者解剖结构特定的模型和植入物。此外,3DP 还用于制备定制的再生医学。本综述重点介绍了 3DP 在制药领域的应用,包括药物输送系统和医疗器械及其制造方法。此外,本文还引用了迄今为止进行的不同临床试验和不同专利。此外,还很好地讨论了与 3D 打印相关的监管问题和未来展望。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验