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3D 打印在制药领域:一项充满挑战的新兴技术。

3D printing in pharmaceuticals: An emerging technology full of challenges.

机构信息

Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), 441 002 India; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), 441 002 India.

Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), 441 002 India; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), 441 002 India.

出版信息

Ann Pharm Fr. 2021 Mar;79(2):107-118. doi: 10.1016/j.pharma.2020.08.007. Epub 2020 Aug 24.

Abstract

Although in its infancy, when compared with the other sectors, year 2005 marked the rapid evolution of 3 Dimensional printing (3DP) technologies in pharma sector with a huge potential in the dosage form designing and personalisation of the medication. 3DP is an innovative and highly promising way for the instant manufacturing in contrast with the tailored made conventional manufacturing. Various 3DP technologies are categorized into the various areas on the basis of the type of material used, deposition techniques and the solidification/fusion techniques. 3DP technologies have multiple pharmaceutical applications including formulation of the precise and unique dosage forms, medical research, personalization of medicine, tissues engineering and surgical application. In the present article, we have accentuated the comparative merits and demerits of various 3DP technologies used in the pharmaceutical sector. An insight in to the challenges, apropos availability and the choice of the excipients, as well as the printer, regulatory and safety concern of the product is provided.

摘要

虽然仍处于起步阶段,但与其他领域相比,2005 年 3D 打印(3DP)技术在制药领域迅速发展,在药物剂型设计和个性化方面具有巨大潜力。3DP 是一种创新且极具前景的即时制造方法,与传统定制制造相比具有优势。各种 3DP 技术根据所用材料的类型、沉积技术和固/熔技术被归类为不同的领域。3DP 技术在药物制剂领域具有多种应用,包括精确和独特的剂型制剂、医学研究、药物个性化、组织工程和外科应用。在本文中,我们强调了制药领域中使用的各种 3DP 技术的优缺点。深入探讨了各种挑战、赋形剂的可获得性和选择、打印机、产品的监管和安全问题。

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