J Am Vet Med Assoc. 2021 Sep 1;259(5):494-502. doi: 10.2460/javma.259.5.494.
To determine whether, in dogs with naïve multicentric lymphoma, neutrophilia at the time of initial diagnosis was associated with progression-free survival time (PFST) or overall response rate (ie, percentage of dogs with a complete or partial remission) and whether the initial neutrophil-to-lymphocyte ratio was associated with PFST.
30 dogs with multicentric lymphoma and neutrophilia (including 16 treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]-based protocol) and 37 historical control dogs without neutrophilia treated with a CHOP-based protocol.
Medical records were reviewed, and PFSTs and responses were documented.
Median PFST for the 16 dogs with neutrophilia treated with a CHOP-based protocol (70 days; range, 0 to 296 days) was significantly shorter than that for the 37 control dogs without neutrophilia (184.5 days; range, 23 to 503 days), and the overall response rate for dogs with neutrophilia (12/16 [75%]) was significantly lower than the rate for dogs without neutrophilia (36/37 [97%]). However, when all dogs in the study and control populations were considered together, the neutrophil-to-lymphocyte ratio at the time of diagnosis was not significantly associated with PFST.
Results suggested that neutrophilia at the time of initial diagnosis may suggest a poorer prognosis in dogs with multicentric lymphoma. Prospective investigation into the role of neutrophils in the peripheral circulation and tumor microenvironment of cancer-bearing patients is warranted.
确定在初诊时患有幼稚性多中心淋巴瘤的犬中，中性粒细胞增多是否与无进展生存期（PFST）或总缓解率（即完全或部分缓解的犬的百分比）相关，以及初始中性粒细胞与淋巴细胞比值是否与 PFST 相关。
30 只患有多中心淋巴瘤和中性粒细胞增多症的犬（包括 16 只接受环磷酰胺、多柔比星、长春新碱和泼尼松（CHOP）方案治疗的犬）和 37 只未发生中性粒细胞增多症的历史对照犬，这些犬接受了 CHOP 方案治疗。
回顾了病历，并记录了 PFST 和反应情况。
接受 CHOP 方案治疗的 16 只中性粒细胞增多症犬的中位 PFST（70 天；范围，0 至 296 天）明显短于未发生中性粒细胞增多症的 37 只对照犬（184.5 天；范围，23 至 503 天），且中性粒细胞增多症犬的总体缓解率（12/16 [75%]）明显低于未发生中性粒细胞增多症的犬（36/37 [97%]）。然而，当研究和对照群体中的所有犬都被一起考虑时，初诊时的中性粒细胞与淋巴细胞比值与 PFST 无显著相关性。
结果表明，初诊时的中性粒细胞增多可能预示着患有多中心淋巴瘤的犬预后较差。有必要对癌症患者外周循环和肿瘤微环境中中性粒细胞的作用进行前瞻性研究。
