Department of Animal Parasitology, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil.
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Parasit Vectors. 2021 Aug 13;14(1):401. doi: 10.1186/s13071-021-04910-3.
The human botfly, Dermatobia hominis, is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule that causes pruritus and pain. Typical treatment consists of sedation for removal of larvae by surgical incision or manual pressure. Medications to kill the larva before its extraction can reduce inflammation and discomfort and provide a less traumatic larval removal. Isoxazolines are broad-spectrum ectoparasiticides with larvicidal activity previously reported in the treatment of screwworm myiasis in companion animals. The aim of this study was to evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs caused by D. hominis larvae.
Ten short-haired mixed breed dogs naturally infested with D. hominis were enrolled. Clinical diagnosis was achieved by observation of skin nodules and visualization of larval motility through the lesion orifice. Sarolaner was administered at manufacturer recommended dose for fleas and ticks. Lesions were reexamined 24 h post-treatment and assessed for viability of larvae. Larvae were removed by digital compression and identified as D. hominis.
Seventy-five D. hominis larvae were retrieved from ten dogs. No live larvae were observed, demonstrating 100% larvicidal efficacy of sarolaner. Skin lesions were healed 30 days post-treatment and new lesions were not observed.
Sarolaner seems to be effective as larvicidal treatment for dogs with furuncular myiasis, reducing discomfort caused by the presence of the larva in the skin and facilitating its safe removal.
人体纹皮蝇，又称肤蝇，是拉丁美洲犬类疖病性蝇蛆病的常见病因。病变可为单发或多发，每个病变中都有一条单独的幼虫，表现为红斑性结节，引起瘙痒和疼痛。典型的治疗方法包括镇静，通过手术切口或手动压力将幼虫取出。在提取幼虫之前使用药物杀死幼虫可以减少炎症和不适，并提供创伤较小的幼虫清除。异恶唑啉类是一种广谱的外寄生虫杀虫剂，先前已报道其具有杀幼虫活性，可用于治疗犬类旋尾线虫蝇蛆病。本研究旨在评估沙罗拉纳作为人类纹皮蝇幼虫引起的犬类疖病性蝇蛆病临床管理的一部分的有效性。
十只短毛混种犬自然感染人体纹皮蝇。通过观察皮肤结节和通过病变口观察幼虫的运动来进行临床诊断。按照制造商推荐剂量给予沙罗拉纳治疗跳蚤和蜱虫。治疗后 24 小时复查病变，评估幼虫的活力。通过数字压缩去除病变，并将幼虫鉴定为人体纹皮蝇。
从十只犬中取出了 75 条人体纹皮蝇幼虫。未观察到活幼虫，表明沙罗拉纳的杀幼虫效果为 100%。治疗后 30 天皮肤病变愈合，未观察到新的病变。
沙罗拉纳似乎是一种有效的犬疖病性蝇蛆病幼虫治疗药物，可减少幼虫在皮肤中存在引起的不适，并有助于安全去除。
