Programa de Pós-graduação em Ciências Veterinárias - PPGCV, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro - UFRRJ, Seropédica, RJ, Brasil.
Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro - UFRRJ, Seropédica, RJ, Brasil.
Rev Bras Parasitol Vet. 2024 Sep 16;33(3):e009524. doi: 10.1590/S1984-29612024054.. eCollection 2024.
An evaluation was made of the larvicidal efficacy of lotilaner (Credeli®) in the treatment of dogs naturally infested with Dermatobia hominis larvae. A total of 12 dogs presenting at least three live D. hominis larvae were medicated. The animals were medicated orally with a single dose of no less than 20 mg/kg lotilaner. After drug administration, the animals remained at their homes, and observations were made to verify the larvicidal effect 6 hours after treatment. Live larvae were considered any parasite that exhibited motility after removal. For each animal was using the formula: 100 x [(total of live larvae before treatment - total live larvae after treatment) /total of live larvae before treatment] as criteria for evaluating lotilaner efficacy. A total of 98 larvae were counted in 12 dogs, with an average of 8.1 larvae per animal. The effectiveness of lotilaner was 80.6%. Nineteen larvae were found alive, albeit presenting hypomobility and lethargic behavior. However, note that the evaluation was performed just six hours after administration of the drug. Lotilaner administered orally in a single dose of 20 mg/kg showed 80.6% efficacy six hours after treating dogs naturally infested with D. hominis.
对利特灵（Credeli®）治疗自然感染人肤蝇幼虫的犬只的杀幼虫效果进行了评估。共有 12 只至少有 3 只活的人肤蝇幼虫的犬只接受了治疗。动物口服给予不少于 20mg/kg 的利特灵单剂量。给药后，动物留在家中，并观察 6 小时后是否有杀幼虫效果。活幼虫是指在取出后仍表现出运动性的任何寄生虫。对于每只动物，使用公式：100 x [(治疗前的总活幼虫数 - 治疗后的总活幼虫数）/治疗前的总活幼虫数]作为评估利特灵疗效的标准。在 12 只狗中，共计数了 98 条幼虫，平均每只动物 8.1 条幼虫。利特灵的有效性为 80.6%。虽然有 19 条幼虫仍然存活，但表现出运动能力降低和嗜睡行为。然而，请注意，该评估是在给药后仅仅 6 小时进行的。在治疗自然感染人肤蝇的犬时，口服给予单剂量 20mg/kg 的利特灵，6 小时后显示出 80.6%的疗效。
