Department of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
J Vet Pharmacol Ther. 2022 Jan;45(1):1-15. doi: 10.1111/jvp.12959. Epub 2021 Mar 17.
The isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on glutamate- and gamma-aminobutyric acid-gated chloride channel located in nervous system of invertebrates. In recent years, studies have been performed to evaluate the efficacy and safety of isoxazolines against various types of ectoparasites, including fleas, ticks, and mites. As more single and combined isoxazoline products have been approved by the United States Food and Drug Administration and European Medicines Agency, a more comprehensive understanding of isoxazolines becomes essential for veterinary clinical practitioners. This article provides a complete review of isoxazolines with respect to pharmacodynamics, pharmacokinetics, ectoparasiticidal efficacy, and safety, which will provide veterinarians information to allow them to make the best choice of ectoparasiticide for their clients' specific needs.
异恶唑啉类是一类新型的外寄生虫抑制剂，对位于无脊椎动物神经系统中的谷氨酸和γ-氨基丁酸门控氯离子通道具有强大的抑制活性。近年来，人们开展了多项研究来评估异恶唑啉类药物对各种类型的外寄生虫（包括跳蚤、蜱虫和螨虫）的疗效和安全性。随着越来越多的单一和联合异恶唑啉类产品获得美国食品药品监督管理局和欧洲药品管理局的批准，兽医临床从业者更需要全面了解异恶唑啉类药物。本文就异恶唑啉类药物的药效学、药代动力学、驱虫效果和安全性进行了全面综述，为兽医提供了相关信息，以便他们根据客户的具体需求选择最佳的驱虫药。
