Department of Anatomy, Histology and Embryology, Kunming Medical University, Kunming, 650500, China.
Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Transl Neurodegener. 2021 Aug 13;10(1):30. doi: 10.1186/s40035-021-00254-1.
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration. PE also regulates brain plasticity, neuroinflammation, and molecular signaling cascades associated with epigenetics. This review summarizes the effects of PE on neurodegenerative diseases via both general and disease-specific DNAm mechanisms, and discusses epigenetic modifications that alleviate the pathological symptoms of these diseases. This may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.
表观遗传时钟由 DNA 甲基化（DNAm）水平定义，已广泛应用于区分生物年龄和实际年龄。与衰老相关的神经退行性变与表观遗传改变有关，它决定了疾病的状态。近年来，大量研究表明，体育锻炼（PE）可以影响 DNAm 水平，暗示神经退行性变中的表观遗传时钟的逆转。PE 还调节与表观遗传学相关的大脑可塑性、神经炎症和分子信号级联。本综述通过一般和特定疾病的 DNAm 机制总结了 PE 对神经退行性疾病的影响，并讨论了减轻这些疾病病理症状的表观遗传修饰。这可能有助于探究神经退行性疾病的基础，并为认知和运动功能障碍提供有价值的治疗参考。
Zotero 插件