Endocrine Research Facility, Dept. of Animal Sciences, Rutgers University, 67 Poultry Farm Lane, New Brunswick, NJ-08901,
Endocrine Research Facility, Dept. of Animal Sciences, Rutgers University, 67 Poultry Farm Lane, New Brunswick, NJ-08901.
Front Biosci (Landmark Ed). 2018 Mar 1;23(8):1445-1464. doi: 10.2741/4654.
Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
表观遗传学涉及多种过程，如 DNA 甲基化、组蛋白密码修饰和非编码 RNA，以调节基因表达。近年来，表观遗传机制的意义在神经科学领域凸显出来，特别是在大脑发育、记忆、学习和各种认知过程中。表观遗传学在大脑衰老过程中也起着关键作用，导致了各种与年龄相关的神经退行性疾病。本文描述了各种表观遗传机制的发现，这些机制在衰老以及与年龄相关的神经退行性疾病（如阿尔茨海默病、帕金森病和亨廷顿病）中起着关键作用及其意义。
