Shephard R J
Can Med Assoc J. 1978 Feb 18;118(4):379-81, 383, 392.
There are many mechanisms whereby recent exposure to cigarette smoke augments the toxicity of common air contaminants: the total pollutant burden is increased, there is cumulative irritation of the airways, pollutants are deposited selectively in the airways, ventilatory patterns are altered, mucus production is increased, ciliary function is depressed, mucosal characteristics are altered, macrophage activity is depressed and specific allergic reactions may occur. In the longer term adverse changes of form and function may develop in the lining of the airways.
近期接触香烟烟雾会增强常见空气污染物毒性，其机制有多种：总污染物负荷增加、气道受到累积性刺激、污染物选择性地沉积在气道中、通气模式改变、黏液分泌增加、纤毛功能受抑制、黏膜特性改变、巨噬细胞活性受抑制，并且可能会发生特定的过敏反应。从长远来看，气道内壁可能会出现形态和功能的不良变化。
