Clarke B G, Guyatt A R, Alpers J H, Fletcher C M, Hill I D
Thorax. 1970 Jul;25(4):418-22. doi: 10.1136/thx.25.4.418.
Measurements of airways conductance using a body plethysmograph were made on 25 men before and after smoking one cigarette on each of four days and before and after a control period without smoking on another day. The repeatability of these measurements and of the bronchoconstrictor effect of smoking was studied. The variance was as great as that observed in a previous field study in industry despite close supervision and a stable environment before the measurements. We think this variation is due to random fluctuation rather than to the lack of close supervision inevitable in a field survey. A second study was made on 16 of the men in which the bronchoconstrictor effect of plain and filtered cigarettes was compared. Filters which removed either the particulate or the vapour phase of the smoke had a similar effect in reducing the bronchoconstrictor response of cigarette smoking.
使用体容积描记器对25名男性进行气道传导率测量，分别在他们连续四天每天吸一支香烟前后，以及在另一天不吸烟的对照期前后进行测量。研究了这些测量结果的可重复性以及吸烟的支气管收缩效应。尽管在测量前有密切监督和稳定环境，但测量结果的方差与之前在工业领域的现场研究中观察到的一样大。我们认为这种变化是由于随机波动，而不是由于现场调查中不可避免地缺乏密切监督。对其中16名男性进行了第二项研究，比较了普通香烟和过滤嘴香烟的支气管收缩效应。去除烟雾颗粒或气相的过滤嘴在降低吸烟的支气管收缩反应方面有类似效果。
