Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou, China.
Clin Otolaryngol. 2021 Nov;46(6):1354-1361. doi: 10.1111/coa.13847. Epub 2021 Aug 20.
We aimed to quantitatively evaluate the degree of endolymphatic hydrops and its correlation with the clinical features of Meniere's disease.
We retrospectively collected data from patients with Meniere's disease who underwent gadolinium-enhanced magnetic resonance imaging (MRI) at our department from January 2018 to December 2019. Mimics software was used to perform three-dimensional modelling of the labyrinth, and volume information was obtained to calculate the endolymphatic hydrops index (EHI). A correlation analysis was conducted with data from pure tone audiometry, electrocochleography (EchoG), vestibular myogenic-evoked potential (VEMP) testing, caloric testing and video head impulse testing (vHIT). A two-dimensional method was also employed to calculate the hydrops ratio (HR) of cochlea and vestibule. The test-retest reliability of EHI/HR from different operators was evaluated.
A total of 23 affected ears were examined, and the EHI was significantly correlated with Meniere's disease stage, low-frequency hearing threshold, EchoG summating potential/action potential ratio (-SP/AP) and VEMP binaural asymmetry ratio, but no significant correlation was observed between EHI and the caloric test or vHIT. The Intraclass correlation coefficient (ICC) of EHI data calculated by two otologists was 0.946 (p < .001). And the ICC of cochlea and vestibule HR were 0.844 and 0.832 (p < .001).
Mimics software can be used to quantitatively evaluate the degree of endolymphatic hydrops and have shown higher test-retest reliability than traditional two-dimensional evaluation method. Endolymphatic hydrops correlates with clinical data, such as Meniere's disease stage, low-frequency hearing threshold, EchoG and VEMP asymmetry ratio.
定量评估内淋巴积水的程度及其与梅尼埃病临床特征的相关性。
回顾性收集 2018 年 1 月至 2019 年 12 月在我科行钆增强磁共振成像（MRI）检查的梅尼埃病患者的临床资料。采用 Mimics 软件对内耳进行三维建模，获取容积信息计算内淋巴积水指数（EHI）。对纯音听阈、电诱发耳声发射（EchoG）、前庭肌源性诱发电位（VEMP）测试、冷热试验和视频头脉冲试验（vHIT）等数据进行相关性分析。采用二维方法计算耳蜗和前庭的积水比（HR）。评估不同操作者的 EHI/HR 测试-再测试的可靠性。
共检查 23 侧患耳，EHI 与梅尼埃病分期、低频听力阈值、EchoG 总和电位/动作电位比值（-SP/AP）和 VEMP 双侧不对称比显著相关，而与冷热试验或 vHIT 无显著相关性。两位耳科医生计算的 EHI 数据的组内相关系数（ICC）为 0.946（p<0.001）。耳蜗和前庭 HR 的 ICC 分别为 0.844 和 0.832（p<0.001）。
Mimics 软件可用于定量评估内淋巴积水的程度，其测试-再测试可靠性高于传统二维评价方法。内淋巴积水与梅尼埃病分期、低频听力阈值、EchoG 和 VEMP 不对称比等临床资料相关。
