双侧梅尼埃病内淋巴积水特征与听力损失的关系。
The relationship between endolymphatic hydrops features and hearing loss in Bilateral Meniere's disease.
机构信息
Department of Otorhinolaryngology, ENT Institute and, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai, 200031, China.
出版信息
Head Face Med. 2024 Sep 16;20(1):50. doi: 10.1186/s13005-024-00455-9.
BACKGROUND
This study aimed to investigate the relationship between the features of endolymphatic hydrops and hearing loss in patients with Bilateral Meniere's Disease.
METHODS
A retrospective analysis was conducted on 77 patients diagnosed with Bilateral Meniere's Disease. The features of endolymphatic hydrops in the affected ear were evaluated through gadolinium-enhanced inner ear Magnetic resonance imaging. The Spearman correlation coefficient, paired t-tests, and Wilcoxon signed-rank tests were employed for data analysis.
RESULTS
The analysis revealed a significant correlation between the degree of endolymphatic hydrops and hearing loss across all frequencies(0.125-8 kHz), including the cochlear, vestibular, and overall degree of endolymphatic hydrops. The strongest correlation between the overall degree of endolymphatic hydrops and hearing loss was observed at low frequencies (r = 0.571, p < 0.05), followed by mid-frequencies (r = 0.508, p < 0.05), and high-frequencies (r = 0.351, p < 0.05), with a correlation of r = 0.463, p < 0.05 for the staging of Meniere's disease. Affected Ears with endolymphatic hydrops both in the cochlea and vestibule exhibited more severe hearing loss and Meniere's disease staging compared to those with isolated endolymphatic hydrops within the same patient.
CONCLUSIONS
The features of endolymphatic hydrops in patients with Bilateral Meniere's Disease were found to correlate with the severity of hearing loss and the staging of Meniere's disease.
背景
本研究旨在探讨双侧梅尼埃病患者内淋巴积水特征与听力损失之间的关系。
方法
对 77 例双侧梅尼埃病患者进行回顾性分析。通过钆增强内耳磁共振成像评估患耳内淋巴积水的特征。采用 Spearman 相关系数、配对 t 检验和 Wilcoxon 符号秩检验进行数据分析。
结果
分析显示，所有频率（0.125-8 kHz）的内淋巴积水程度与听力损失之间存在显著相关性，包括耳蜗、前庭和总体内淋巴积水程度。总体内淋巴积水程度与听力损失之间的相关性最强，在低频（r=0.571，p<0.05），中频（r=0.508，p<0.05）和高频（r=0.351，p<0.05）。梅尼埃病分期的相关性为 r=0.463，p<0.05。与同一患者中孤立的内淋巴积水相比，同时伴有耳蜗和前庭内淋巴积水的患耳表现出更严重的听力损失和梅尼埃病分期。
结论
双侧梅尼埃病患者的内淋巴积水特征与听力损失的严重程度和梅尼埃病的分期相关。
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