Armitage J O, Dick F R, Corder M P
Cancer. 1978 Feb;41(2):422-7. doi: 10.1002/1097-0142(197802)41:2<422::aid-cncr2820410207>3.0.co;2-x.
Nine patients with chronic lymphocytic leukemia (CLL) who also developed diffuse histiocytic lymphoma (DH) are described. The incidence of patients with CLL developing DH was at least 3.3%. CLL existed for a median of 2 years before the diagnosis of DH. DH presented in 8 patients with abdominal symptoms and/or enlarging lymph nodes, spleen and liver. There were no consistent laboratory abnormalities associated with the onset of DH. In 4 of the patients the DH appeared to be localized. Eight of the 9 patients have died with a median survival of 2 months from the diagnosis of DH. Whether DH occurs as a result of "blastic transformation" of pre-existing CLL or is a second, unrelated malignancy is not certain. It is hypothesized that utilizing current therapies for DH might favorably influence survival.
本文描述了9例慢性淋巴细胞白血病（CLL）患者，这些患者同时还发生了弥漫性组织细胞淋巴瘤（DH）。CLL患者发生DH的发生率至少为3.3%。在诊断出DH之前，CLL的中位存在时间为2年。8例患者的DH表现为腹部症状和/或淋巴结、脾脏及肝脏肿大。与DH发病相关的实验室检查结果并无一致性。4例患者的DH似乎为局限性。9例患者中有8例已死亡，自诊断出DH起的中位生存期为2个月。DH是由预先存在的CLL“原始细胞转化”导致，还是第二种不相关的恶性肿瘤，目前尚不确定。据推测，采用当前针对DH的治疗方法可能对生存期产生有利影响。
