从 APOE e3/e3 基因型的阿尔茨海默病患者中生成诱导多能干细胞系。
Generation of inducible pluripotent stem cell lines from Alzheimer's disease patients with APOE e3/e3 genotype.
机构信息
Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Clinical and Diagnoistic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Stem Cell Res. 2021 Aug;55:102498. doi: 10.1016/j.scr.2021.102498. Epub 2021 Aug 10.
iPSCs were generated from B lymphocytes of two Alzheimer's disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments.
我们从两名载脂蛋白 E ɛ3 等位基因纯合子的阿尔茨海默病（AD）患者的 B 淋巴细胞中生成了 iPSCs。这些 iPSCs 表达多能性特异性标志物，并具有分化为所有三个胚胎 germ 层的能力。染色体组型分析证实 iPSCs 具有正常的染色体组型。这些 iPSCs 可被用作体外模型来研究 AD 并评估新疗法的疗效。
Zotero 插件