The Ocular Surface Institute, College of Optometry, University of Houston, Houston, Texas.
Optom Vis Sci. 2021 Aug 1;98(8):983-994. doi: 10.1097/OPX.0000000000001753.
Multifocal contact lenses (MFCLs) are being used clinically for myopia control. Center-distance designs caused myopic changes in defocus across the retina that varied by lens design, whereas the center-near design caused peripheral hyperopic changes. Multifocal lenses caused reductions in low-contrast vision that varied by lens design, affecting visual performance.
The purpose of this study was to compare changes in defocus with four MFCLs, three center-distance and one center-near.
Two cohorts of 25 nonpresbyopic myopic adults were enrolled. The first cohort was fitted with Proclear D and Biofinity D MFCL (center-distance, +2.50 D add), and the second cohort was fitted with NaturalVue MFCL (center-distance) and Clariti 1-Day MFCL (center-near, high add), both in random order. Overrefraction was performed to maximize visual acuity. Cycloplegic autorefraction was performed with each lens and without a lens along the line of sight and at nasal and temporal retinal locations out to 40°. Data were analyzed with repeated-measures ANOVAs with post hoc t tests, when indicated.
Changes in defocus at each location differed between MFCL designs (lens by location; both, P < .001). Clariti 1-Day caused peripheral hyperopic retinal changes (40 and 30° nasal, and 20, 30, and 40° temporal; all, P < .05). NaturalVue MFCL caused myopic changes centrally and hyperopic changes at 40° nasal and 30° temporal (all, P < .05). The remaining center-distance designs caused myopic changes at multiple locations (all, P < .05).
After overrefraction, the center-near MFCL design caused hyperopic defocus at multiple peripheral locations, which is not hypothesized to slow myopia progression. NaturalVue MFCL caused myopic changes in defocus centrally but hyperopic changes in the far periphery. Biofinity D and Proclear D caused myopic changes in retinal defocus. Further work is warranted to determine whether defocus profile differences between the center-distance designs influence any slowing of myopia progression.
多焦点隐形眼镜 (MFCL) 目前正在临床用于近视控制。中心距离设计在视网膜上引起了不同的离焦近视变化，这取决于镜片设计，而中心近设计则引起周边远视变化。多焦点镜片导致不同的低对比度视力下降，这取决于镜片设计，影响视觉性能。
本研究旨在比较四种 MFCL（三种中心距离和一种中心近）的离焦变化。
共招募了 25 名非远视近视成年人的两个队列。第一队列适配了 Proclear D 和 Biofinity D MFCL（中心距离，+2.50 D 附加），第二队列随机适配了 NaturalVue MFCL（中心距离）和 Clariti 1-Day MFCL（中心近，高附加）。进行过矫以最大限度地提高视力。在每个镜片和视线无镜片以及鼻侧和颞侧视网膜位置到 40°处进行睫状肌麻痹自动折射。使用重复测量方差分析和事后 t 检验对数据进行分析，必要时。
不同 MFCL 设计的每个位置的离焦变化不同（镜片与位置；均，P <.001）。Clariti 1-Day 引起周边远视性视网膜变化（40°和 30°鼻侧，以及 20°、30°和 40°颞侧；均，P <.05）。NaturalVue MFCL 引起中央近视变化和 40°鼻侧和 30°颞侧的远视变化（均，P <.05）。其余的中心距离设计在多个位置引起近视变化（均，P <.05）。
过矫后，中心近 MFCL 设计在多个周边位置引起远视离焦，这不会减缓近视进展。NaturalVue MFCL 在中央引起近视离焦，但在远周边引起远视变化。Biofinity D 和 Proclear D 引起视网膜离焦的近视变化。需要进一步的工作来确定中心距离设计之间的离焦分布差异是否会影响任何减缓近视进展的作用。
