Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China.
Front Endocrinol (Lausanne). 2021 Jul 28;12:721213. doi: 10.3389/fendo.2021.721213. eCollection 2021.
Type 2 diabetes mellitus (T2DM) patients have a lower risk of abdominal aortic aneurysm (AAA) and its comorbidities, which might be associated with the usage of metformin. The objective of the study was to evaluate the role of metformin in the process of AAA development.
PubMed, Embase and Cochrane Library were searched up to May 15, 2021. We implemented several methods including the risk of bias graph, GRADE system and funnel plot to assess the quality and possible bias of this study. Subgroup analysis and sensitivity analysis were applied to address quality differences and validate the robustness of the final results.
Ten articles were enrolled after screening 151 articles searched from databases. The pooled results showed that, compared with T2DM patients without metformin, metformin prescription was associated with a slower annual growth rate of the aneurysm (mean difference (MD) -0.67 cm [95% confidence interval (CI) -1.20 ~ -0.15 cm]). Besides, metformin exposure was associated with a lower frequency of AAA events (odds ratio (OR) 0.61 [95% CI 0.41-0.92]).
Metformin alleviated both annual expansion rate and aneurysm rupture frequency in AAA patients with T2DM.
PROSPERO, identifier https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=217859 (CRD42020217859).
2 型糖尿病（T2DM）患者发生腹主动脉瘤（AAA）及其合并症的风险较低，这可能与二甲双胍的使用有关。本研究旨在评估二甲双胍在 AAA 发展过程中的作用。
检索 PubMed、Embase 和 Cochrane Library 数据库，截至 2021 年 5 月 15 日。我们采用风险偏倚图、GRADE 系统和漏斗图等方法评估了该研究的质量和可能存在的偏倚。亚组分析和敏感性分析用于解决质量差异，验证最终结果的稳健性。
经数据库筛选出的 151 篇文章中，有 10 篇文章被纳入。汇总结果显示，与未使用二甲双胍的 T2DM 患者相比，二甲双胍处方与 AAA 瘤体的年增长率较慢相关（平均差异（MD）-0.67cm[95%置信区间（CI）-1.20-0.15cm]）。此外，二甲双胍暴露与 AAA 事件的发生频率较低相关（比值比（OR）0.61[95%CI 0.410.92]）。
二甲双胍可降低 T2DM 合并 AAA 患者的瘤体年增长率和瘤体破裂频率。
PROSPERO，标识符 https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=217859（CRD42020217859）。
