Wu Xun, Wang Yunting, Ren Ziyu, Li Linman, Qian Wenjie, Chen Yue, Ren Wei
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Int J Endocrinol. 2021 Aug 6;2021:5921863. doi: 10.1155/2021/5921863. eCollection 2021.
Patients with adult growth hormone deficiency (AGHD) confer a heightened risk of cardiovascular disease and increased mortality because of metabolic disorders. Growth differentiation factor-15 (GDF-15) plays an important role in predicting metabolic abnormalities. We sought to investigate the correlation between GDF-15 and cardiovascular risk in AGHD patients.
The study enrolled 80 AGHD patients and 80 healthy subjects. We analyzed the association between GDF-15 and some major biochemical indicators. The potential association between GDF-15 and cardiovascular disease risk was analyzed.
The AGHD group exhibited increased waist-hip ratio and high-sensitivity C-reactive protein (hs-CRP) and lipid levels compared with the healthy control group. Serum GDF-15 levels in AGHD group were elevated significantly compared with the control group ( < 0.001). GDF-15 levels were negatively associated with insulin-like growth factor-1 in AGHD group (=0.006) and positively correlated with waist-to-hip ratio (=0.018), triglycerides (=0.007), and hs-CRP (=0.046). In addition, GDF-15 was positively correlated with Framingham risk score significantly after adjustment for other factors ( = 0.497, < 0.001). Moreover, GDF-15 was an independent risk factor for cardiovascular disease in AGHD patients after adjusting for traditional cardiovascular risk factors.
Elevated GDF-15 levels were significantly associated with cardiovascular risk factors and can be considered as a predictive biomarker of cardiovascular risk in AGHD patients.
成年生长激素缺乏症（AGHD）患者由于代谢紊乱，心血管疾病风险增加，死亡率上升。生长分化因子-15（GDF-15）在预测代谢异常方面发挥着重要作用。我们旨在研究AGHD患者中GDF-15与心血管风险之间的相关性。
该研究纳入了80例AGHD患者和80名健康受试者。我们分析了GDF-15与一些主要生化指标之间的关联。分析了GDF-15与心血管疾病风险之间的潜在关联。
与健康对照组相比，AGHD组的腰臀比、高敏C反应蛋白（hs-CRP）和血脂水平升高。AGHD组的血清GDF-15水平与对照组相比显著升高（<0.001）。AGHD组中，GDF-15水平与胰岛素样生长因子-1呈负相关（=0.006），与腰臀比（=0.018）、甘油三酯（=0.007）和hs-CRP（=0.046）呈正相关。此外，在调整其他因素后，GDF-15与弗雷明汉风险评分显著正相关（=0.497，<0.001）。而且，在调整传统心血管危险因素后，GDF-15是AGHD患者心血管疾病的独立危险因素。
GDF-15水平升高与心血管危险因素显著相关，可被视为AGHD患者心血管风险的预测生物标志物。
