Watanabe M, Baba T, Hotchi M
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Acta Pathol Jpn. 1987 Nov;37(11):1845-51. doi: 10.1111/j.1440-1827.1987.tb02877.x.
An extremely rare case of leiomyoma originating in the lamina muscularis mucosae of the esophagus with a complication of carcinoma in situ in its overlying mucosa was reported. The patient was a 53-year-old male who complained of a feeling of abdominal fullness. A small, elevated tumor was found in the middle portion of the esophagus by esophagoscopy. Biopsy specimens showed it to be squamous cell carcinoma. The resected material revealed the tumor mass to be composed of both a leiomyoma, measuring 0.8 x 0.6 x 0.25 cm, which continued from the lamina muscularis mucosae, and carcinoma in situ and dysplasia in the overlying mucosa of the leiomyoma. The mucosa apart from that covering the leiomyoma was intact. It was speculated that chronic stimulation of the epithelium covering the leiomyoma might have induced the dysplasia and carcinoma in situ.
报告了一例极为罕见的起源于食管黏膜肌层的平滑肌瘤，其上方黏膜并发原位癌的病例。患者为一名53岁男性，主诉腹胀。经食管镜检查发现食管中部有一个小的隆起性肿瘤。活检标本显示为鳞状细胞癌。切除的组织显示肿瘤块由一个平滑肌瘤（大小为0.8×0.6×0.25 cm，起源于黏膜肌层）以及平滑肌瘤上方黏膜的原位癌和发育异常组成。除覆盖平滑肌瘤的黏膜外，其余黏膜完整。推测覆盖平滑肌瘤的上皮长期受到刺激可能诱发了发育异常和原位癌。
