Takiyama W, Moriwaki S, Mandai K, Hara K, Doihara H, Takashima S
Dept. of Surgery, Shikoku Cancer Center Hospital.
Gan No Rinsho. 1989 Jul;35(8):933-8.
To clarify the histogenesis of squamous cell carcinoma of esophagus, 307 esophagus resected from autopsied cases have been thoroughly examined. These specimens were dyed with Lugol solution and entirely blocked to study subserial sections. Among these specimens, two subclinically superficial squamous cell carcinomas were found. First case uncovered was that of a woman who had died of a carcinoma of uterus. Microscopic examination revealed a small carcinoma in situ, located in the cervical portion of the esophagus, though this lesion showed no associated dysplasia. The other case was that of an old man who had died of a massive hemorrhage from a gastric ulcer, associated with carcinomas of the lip, liver, and prostate. The esophageal lesion was an intramucosal carcinoma located in the mid esophagus that was encountered with moderate dysplasia. These examples are not only quite rare as being multiple primary carcinomas but they also suggest two possible types of cancer development of the esophagus: one that progresses from normal mucosa, and the other from dysplastic mucosa.
为阐明食管鳞状细胞癌的组织发生，对307例尸检病例的食管切除标本进行了全面检查。这些标本用卢戈氏溶液染色并全部包埋以研究连续切片。在这些标本中，发现了两例亚临床浅表性鳞状细胞癌。首例发现的是一名死于子宫癌的女性。显微镜检查显示在食管颈部有一个小的原位癌，尽管该病变未伴有发育异常。另一例是一名死于胃溃疡大出血的老年男性，同时伴有唇癌、肝癌和前列腺癌。食管病变是位于食管中段的黏膜内癌，伴有中度发育异常。这些例子不仅作为多原发性癌相当罕见，而且还提示了食管癌发展的两种可能类型：一种从正常黏膜发展而来，另一种从发育异常的黏膜发展而来。
