Hussein Ahmed M, Bezu Mekite, Korz Volker
Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
Zoology Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
Bio Protoc. 2018 Jul 20;8(14):e2930. doi: 10.21769/BioProtoc.2930.
Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs-either one-time or through daily injection-can elucidate the underlying mechanisms. The T-maze is especially suitable for studying dopamine-dependent working memory, since it is less stressful than other tests, for example, water maze-based paradigms ( Bezu , 2016 and 2017). Here, we present a training protocol for evaluating the underlying mechanisms that lead to the development of spatial working memory in rats. Our approach uses a T-maze, and it can be used to get high temporal resolution.
工作记忆属于短期记忆，因此随时间推移而产生的改善并不反映记忆痕迹的巩固，而是反映潜在神经回路和分子信号级联的功能。一次性给药或每日注射药物可以阐明其潜在机制。T迷宫特别适合用于研究多巴胺依赖的工作记忆，因为它比其他测试（例如基于水迷宫的实验范式）压力更小（Bezu，2016年和2017年）。在此，我们提出一种训练方案，用于评估导致大鼠空间工作记忆发展的潜在机制。我们的方法使用T迷宫，并且可用于获得高时间分辨率。
