在雄性大鼠的T型迷宫中评估工作记忆
Evaluating Working Memory on a T-maze in Male Rats.
作者信息
Hussein Ahmed M, Bezu Mekite, Korz Volker
机构信息
Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
Zoology Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
出版信息
Bio Protoc. 2018 Jul 20;8(14):e2930. doi: 10.21769/BioProtoc.2930.
Abstract
Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs-either one-time or through daily injection-can elucidate the underlying mechanisms. The T-maze is especially suitable for studying dopamine-dependent working memory, since it is less stressful than other tests, for example, water maze-based paradigms ( Bezu , 2016 and 2017). Here, we present a training protocol for evaluating the underlying mechanisms that lead to the development of spatial working memory in rats. Our approach uses a T-maze, and it can be used to get high temporal resolution.
摘要
工作记忆属于短期记忆，因此随时间推移而产生的改善并不反映记忆痕迹的巩固，而是反映潜在神经回路和分子信号级联的功能。一次性给药或每日注射药物可以阐明其潜在机制。T迷宫特别适合用于研究多巴胺依赖的工作记忆，因为它比其他测试（例如基于水迷宫的实验范式）压力更小（Bezu，2016年和2017年）。在此，我们提出一种训练方案，用于评估导致大鼠空间工作记忆发展的潜在机制。我们的方法使用T迷宫，并且可用于获得高时间分辨率。
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