尿苷三乙酸酯治疗胸苷酸合成酶基因变异患者的严重氟嘧啶心脏毒性 - Suppr

Uridine Triacetate for Severe Fluoropyrimidine Cardiotoxicity in a Patient With Thymidylate Synthase Gene Variants.

作者信息

Raber Inbar, Frazer Morgan B, Zerillo Jessica A, Asnani Aarti

机构信息

Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

出版信息

JACC CardioOncol. 2020 Jun 16;2(2):329-332. doi: 10.1016/j.jaccao.2020.04.005. eCollection 2020 Jun.

DOI:10.1016/j.jaccao.2020.04.005

PMID:34396241

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8352086/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9026/8352086/6fe81fe19663/gr1.jpg

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Fluoropyrimidine-Associated Cardiotoxicity: A Retrospective Case-Control Study.氟嘧啶类药物相关性心脏毒性：一项回顾性病例对照研究。

Oncologist. 2020 Mar;25(3):e606-e609. doi: 10.1634/theoncologist.2019-0762. Epub 2019 Dec 16.

DPD testing must remain a recommended option, but not a recommended routine test.二氢嘧啶脱氢酶（DPD）检测必须仍是一种推荐的选择，但不是推荐的常规检测。

Ann Oncol. 2017 Jun 1;28(6):1399. doi: 10.1093/annonc/mdx118.

Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.尿苷三乙酸酯在预防和治疗危及生命的5-氟尿嘧啶和卡培他滨毒性中的紧急使用。

Cancer. 2017 Jan 1;123(2):345-356. doi: 10.1002/cncr.30321. Epub 2016 Sep 13.

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.ESMO 共识指南：转移性结直肠癌患者的管理。

Ann Oncol. 2016 Aug;27(8):1386-422. doi: 10.1093/annonc/mdw235. Epub 2016 Jul 5.

DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).DPYD基因变异作为辅助性结肠癌治疗中5-氟尿嘧啶毒性的预测指标（NCCTG N0147）

J Natl Cancer Inst. 2014 Nov 7;106(12). doi: 10.1093/jnci/dju298. Print 2014 Dec.

Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.临床药物遗传学实施联盟指南：二氢嘧啶脱氢酶基因型与氟嘧啶类药物剂量。

Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29.

Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors.接受氟尿嘧啶或卡培他滨治疗的癌症患者的心脏毒性：发生率、表现和易患因素的系统评价。

Cancer Treat Rev. 2013 Dec;39(8):974-84. doi: 10.1016/j.ctrv.2013.03.005. Epub 2013 Apr 10.

Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians.与白种人相比，非裔美国人中二氢嘧啶脱氢酶缺乏症的患病率更高。

Clin Cancer Res. 2006 Sep 15;12(18):5491-5. doi: 10.1158/1078-0432.CCR-06-0747.

Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.胸苷酸合成酶基因多态性可预测接受基于5-氟尿嘧啶化疗的结直肠癌患者的毒性。

Clin Cancer Res. 2004 Sep 1;10(17):5880-8. doi: 10.1158/1078-0432.CCR-04-0169.

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels.胸苷酸合成酶基因中的一个6碱基对多态性导致信使不稳定，并与肿瘤内TS mRNA水平降低相关。

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Uridine Triacetate for Severe Fluoropyrimidine Cardiotoxicity in a Patient With Thymidylate Synthase Gene Variants.

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