Population Health Sciences, University of Bristol, Bristol, United Kingdom.
National Institute for Health Research Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom.
J Infect Dis. 2021 Aug 16;224(12 Suppl 2):S128-S136. doi: 10.1093/infdis/jiab088.
Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection worldwide, has been widely researched for its involvement in many disease pathologies in the reproductive tract, including pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility. Recent findings, through the efforts to understand the pathogenesis of CT, suggest that CT can induce the process of epithelial-to-mesenchymal transition (EMT) through epigenetic changes in the epithelium of the female reproductive tract. This literature review aims to analyze the evidence for CT's ability to promote EMT and to pinpoint the areas that merit further investigation.
沙眼衣原体（CT）是全球最常见的细菌性性传播感染病原体，其广泛参与生殖道多种疾病病理过程的研究已较为深入，包括盆腔炎、宫外孕和输卵管性不孕。通过努力理解 CT 的发病机制，最近的研究结果提示 CT 可通过女性生殖道上皮的表观遗传改变诱导上皮-间充质转化（EMT）过程。本文献综述旨在分析 CT 促进 EMT 的能力的证据，并确定值得进一步研究的领域。
