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[恶性贫血患者的希林试验,假阴性反应问题。附病例报告]

[The Schilling test in Biermer's disease, problems of false negative reactions. Apropos of a case].

作者信息

Devidas A, Jeantils V, Soulier A, Lejeune F, Delzant G

机构信息

Laboratoire d'Hématologie, Hôpital Jean-Verdier, Bondy.

出版信息

Ann Med Interne (Paris). 1987;138(7):494-7.

PMID:3439671
Abstract

A case of pernicious anemia in a 30 years old men is described. This disease was typical for the hematologic, immunologic and medullary patterns, for his evolution, but the Schilling test, a dual tracer method, did not confirm the diagnosis. The contradictory of this result can be explained wether by the bias of the test itself, or by the intestinal malabsorption due to the vitamin B12 deficiency, or by other factors like bacterial overgrowth state (associated in the pernicious anemia) and a high level of antibodies to intrinsic factor.

摘要

描述了一名30岁男性患恶性贫血的病例。这种疾病在血液学、免疫学和骨髓模式及其发展过程中具有典型特征,但采用双示踪剂法的希林试验并未证实该诊断。这一结果的矛盾之处可以通过试验本身的偏差、维生素B12缺乏导致的肠道吸收不良,或其他因素如细菌过度生长状态(与恶性贫血相关)以及内因子抗体水平升高等来解释。

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[Biermer's anemia].
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