Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Cutis. 2021 Jul;108(1):43-45. doi: 10.12788/cutis.0291.
Isotretinoin is one of the most effective drugs for the treatment of all forms of acne vulgaris. It has been suspected of causing alterations in lipids and liver enzymes. The aim of this retrospective study was to determine the prevalence of laboratory changes among 371 patients with acne receiving isotretinoin therapy. Each patient's medical records were evaluated to determine baseline alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, and triglycerides (TGs) compared to levels recorded at 2 later readings following initiation of treatment with oral isotretinoin. Results indicated that isotretinoin can be administered with minimal concern regarding changes in serum transaminase and lipid profiles. Nevertheless, physicians should be cautious when administering isotretinoin in patients with a history of abnormal findings.
异维 A 酸是治疗各种寻常痤疮最有效的药物之一。它已被怀疑会引起血脂和肝酶的变化。本回顾性研究的目的是确定 371 例接受异维 A 酸治疗的痤疮患者的实验室变化发生率。评估每位患者的病历，以确定与开始口服异维 A 酸治疗后 2 次随访记录的水平相比，基线丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、总胆固醇和甘油三酯（TGs）的水平。结果表明，异维 A 酸治疗可引起血清转氨酶和脂质谱的变化，但不用担心。然而，对于有异常发现史的患者，医生在使用异维 A 酸时应谨慎。
