类花生酸途径中的细胞间相互作用。

Cell-cell interactions in the eicosanoid pathway.

作者信息

Marcus A J, Safier L B, Ullman H L, Islam N, Broekman M J, Falck J R, Fischer S, von Schacky C

机构信息

Department of Medicine, New York Veterans Administration Medical Center, Cornell University Medical College, New York 10010.

出版信息

Ann N Y Acad Sci. 1987;516:407-11. doi: 10.1111/j.1749-6632.1987.tb33059.x.

DOI:10.1111/j.1749-6632.1987.tb33059.x

PMID:3439737

Abstract

In vitro experiments carried out in several laboratories indicate that cell components of hemostatic plugs, thrombi, and inflammatory lesions are capable of sharing precursors and intermediates of both the lipoxygenase and cyclooxygenase systems. These cells produce new eicosanoids in a stimulus-specific manner. It is therefore important to further elucidate mechanisms by which eicosanoids are formed during cell-cell interactions and the functional implications thereof.

摘要

几个实验室进行的体外实验表明，止血栓、血栓和炎症病变的细胞成分能够共享脂氧合酶和环氧化酶系统的前体和中间体。这些细胞以刺激特异性的方式产生新的类花生酸。因此，进一步阐明细胞间相互作用过程中类花生酸的形成机制及其功能意义非常重要。