Department of Healthcare Administration, Asia University, Taichung, Taiwan.
BenQ medical center, Emergency Department, Nanjing, China.
Medicine (Baltimore). 2021 Jul 23;100(29):e26627. doi: 10.1097/MD.0000000000026627.
Previous investigations yielded inconsistent results for diagnostic and prognostic predictive values of MicroRNAs (miRNAs) for acute myocardial infarction (AMI).
We systematically searched on PubMed and Web of Science for articles explored association of miRNAs and AMI published from January 1989 to March 2019. For diagnostic studies, a summary of sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR), which indicated the accuracy of microRNAs in the differentiation of AMI and no AMI, were calculated from the true positive (TP), true negative (TN), false positive (FP), and false negative (FN) of each study. In addition, the summary receive-operating characteristics (SROC) curve was constructed to summarize the TP and FP rates. For follow-up study, we computed hazard ratios (HRs) and 95% confidence intervals (CIs) for individual clinical outcomes. The meta-analysis showed a sensitivity [0.72 (95% CI: 0.61--0.81)] and specificity [0.88 (95% CI: 0.79--0.94)] of miR-1 for AMI. In addition, miR-133 showed a sensitivity [0.73 (95% CI: 0.55--0.85)] and specificity [0.88 (95% CI: 0.74--0.95)] for AMI. Moreover, the present study showed a sensitivity [0.83 (95% CI: 0.74--0.89)] and specificity [0.96 (95% CI: 0.82--0.99)] of miR-208 for AMI. A significant association was found between miR-208 and mortality after AMI (HR 1.09, 95% CI 1.01--1.18). It also indicated a sensitivity [0.84 (95% CI: 0.70--0.92)] and specificity [0.97 (95% CI: 0.87--0.99)] of miR-499 for AMI.
Circulating miR-1, miR-133, miR-208, and miR-499 showed diagnostic values in AMI.
先前的研究对于 microRNAs（miRNAs）在急性心肌梗死（AMI）中的诊断和预后预测价值得出了不一致的结果。
我们在 PubMed 和 Web of Science 上系统地搜索了自 1989 年 1 月至 2019 年 3 月发表的探讨 miRNA 与 AMI 相关性的文章。对于诊断研究，从每个研究的真阳性（TP）、真阴性（TN）、假阳性（FP）和假阴性（FN）中计算了 miRNA 在区分 AMI 和非 AMI 中的准确性的汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断比值比（DOR）。此外，还构建了汇总接收者操作特征（SROC）曲线以总结 TP 和 FP 率。对于随访研究，我们计算了各个临床结局的风险比（HR）和 95%置信区间（CI）。荟萃分析显示，miR-1 对 AMI 的敏感性为[0.72（95%CI：0.61--0.81）]和特异性为[0.88（95%CI：0.79--0.94）]。此外，miR-133 对 AMI 的敏感性为[0.73（95%CI：0.55--0.85）]和特异性为[0.88（95%CI：0.74--0.95）]。此外，本研究显示 miR-208 对 AMI 的敏感性为[0.83（95%CI：0.74--0.89）]和特异性为[0.96（95%CI：0.82--0.99）]。miR-208 与 AMI 后死亡率之间存在显著相关性（HR 1.09，95%CI 1.01--1.18）。miR-499 对 AMI 的敏感性为[0.84（95%CI：0.70--0.92）]和特异性为[0.97（95%CI：0.87--0.99）]。
循环 miR-1、miR-133、miR-208 和 miR-499 在 AMI 中具有诊断价值。
