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大鼠体内源自苯并噻唑基亚磺酰胺的2-硫代苯并噻唑代谢物巯基中硫原子的代谢来源。

The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thiobenzothiazole metabolites derived from benzothiazyl sulfenamide in the rat.

作者信息

Fukuoka M, Tanaka A

机构信息

Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.

出版信息

Arch Toxicol. 1987 Dec;61(2):158-60. doi: 10.1007/BF00661376.

DOI:10.1007/BF00661376
PMID:3439889
Abstract

After administration of benzothiazyl sulfenamide to rats, over 90% of the S atom in the sulfhydryl group was retained in 2-thiobenzothiazole metabolites. The S atom in 2-benzothiazyl mercapturic acid, a major metabolite, was mostly replaced by the endogenous S from the L-cysteine pool.

摘要

给大鼠施用苯并噻唑基亚磺酰胺后，巯基中超过90%的硫原子保留在2-硫代苯并噻唑代谢物中。主要代谢物2-苯并噻唑基硫醚氨酸中的硫原子大部分被来自L-半胱氨酸池的内源性硫取代。

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The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thiobenzothiazole metabolites derived from benzothiazyl sulfenamide in the rat.大鼠体内源自苯并噻唑基亚磺酰胺的2-硫代苯并噻唑代谢物巯基中硫原子的代谢来源。
Arch Toxicol. 1987 Dec;61(2):158-60. doi: 10.1007/BF00661376.
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引用本文的文献

1
Metabolism of 2-thiobenzothiazoles in the rat. Urinary, fecal and biliary metabolites of 2-benzothiazyl sulfenamides.大鼠体内2-硫代苯并噻唑的代谢。2-苯并噻唑基亚磺酰胺的尿液、粪便和胆汁代谢物。
Arch Toxicol. 1995;70(1):1-9. doi: 10.1007/s002040050241.

本文引用的文献

1
THE BIOTRANSFORMATION OF A SULFONAMIDE TO A MERCAPTAN AND TO MERCAPTURIC ACID AND GLUCURONIDE CONJUGATES.
Biochem Pharmacol. 1965 Apr;14:457-66. doi: 10.1016/0006-2952(65)90218-2.
2
Acquirement of fetal properties in hepatoma on glutathione metabolism.肝癌中谷胱甘肽代谢的胎儿特性获得
Biochim Biophys Acta. 1974 Jul 4;354(2):161-7. doi: 10.1016/0304-4165(74)90001-4.