Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, 310003,China.
Key Laboratory for Drug Evaluation and Clinical Research of Zhejiang Province, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003,China.
Int J Med Sci. 2021 Jul 25;18(14):3326-3332. doi: 10.7150/ijms.61500. eCollection 2021.
Ameloblastoma is an odontogenic tumor occurring in jaws, with local aggressiveness and postoperative recurrence. This study was aim to investigate the clinical and radiographic risk factors for recurrence in ameloblastoma. Patients diagnosed with ameloblastoma between March 2009 and March 2019 were retrospectively analyzed. Clinical and Radiological data and follow-up records were collected. Survival analyses were performed by Kaplan-Meier and log-rank tests, as well as Cox proportional hazards model. One hundred and fifty-eight patients (104 males and 54 females were enrolled. The overall recurrence rate for ameloblastoma was 13.29%, and 10.76% recurred within 5 years. Most of the tumors were located in mandible (86.71%), while the rest 21 cases were in maxilla (13.29%). More than half cases (55.06%) showed multilocular radiolucency, 61 cases (38.61%) showed unilocular radiolucency. Significant differences were found with amelobastoma recurrence rate related to treatment modality, impacted tooth and root resorption (P =0.002, 0.022 and 0.007 respectively). Treatment modality, impacted tooth and root resorption all showed statistically significant associations with the recurrence rate in ameloblastoma. However, due to the limitation of this study, further studies are needed to reveal the true mechanism of ameloblastoma recurrence.
成釉细胞瘤是一种发生在颌骨的牙源性肿瘤，具有局部侵袭性和术后复发的特点。本研究旨在探讨成釉细胞瘤复发的临床和影像学危险因素。
回顾性分析了 2009 年 3 月至 2019 年 3 月期间诊断为成釉细胞瘤的患者。收集了临床和影像学数据以及随访记录。采用 Kaplan-Meier 和对数秩检验以及 Cox 比例风险模型进行生存分析。
共纳入 158 例患者（104 例男性，54 例女性）。成釉细胞瘤的总体复发率为 13.29%，5 年内复发率为 10.76%。大多数肿瘤位于下颌骨（86.71%），其余 21 例位于上颌骨（13.29%）。超过一半的病例（55.06%）表现为多房性透光性，61 例（38.61%）表现为单房性透光性。治疗方式、埋伏牙和牙根吸收与成釉细胞瘤的复发率有显著差异（P=0.002、0.022 和 0.007）。
治疗方式、埋伏牙和牙根吸收均与成釉细胞瘤的复发率有统计学关联。然而，由于本研究的局限性，需要进一步的研究来揭示成釉细胞瘤复发的真正机制。
