Smit Chané, Robinson Liam, van Heerden Marlene B, Meyer Pieter W, Fonseca Felipe P, van Heerden Willie F P, Uys André
Department of Oral and Maxillofacial Pathology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
J Oral Pathol Med. 2025 Mar;54(3):161-172. doi: 10.1111/jop.13611. Epub 2025 Jan 30.
The study aimed to assess the radiologic-specific growth rate of ameloblastomas, evaluating potential associations with demographics, radiologic features, histopathologic variants and proliferation indices. The results of this study will hopefully establish if any clinical or histopathologic features can elude fast-growing ameloblastomas.
Patients presenting with multiple radiographs before surgical intervention due to various healthcare constraints or patient factors were included in the study. The measurements from each radiograph included the lesion's length, height, width and amount of expansion in these dimensions. Furthermore, the circumference of the lesion was measured in sagittal, coronal and axial planes. The radiologic-specific growth rate was assessed by calculating the difference in measurements from the initial to follow-up radiographs divided by the duration between the visits to calculate the growth rate per year.
The specific growth rate was analysed between age groups, histopathologic variants and Ki-67 values, with no statistically significant correlations found in all dimensions measured. A statistically significant faster growth (p = 0.04) was seen in females when measuring the mesial-distal length. When comparing radiologic features, ameloblastomas with loss of border demarcation, severe cortical destruction and tooth displacement demonstrated statistically significant faster growth.
This study found significant correlations with the growth rate of ameloblastomas, specifically in coronal dimensions, supporting the notion of buccal-lingual growth/expansion for which ameloblastomas are known.
本研究旨在评估成釉细胞瘤的放射学特定生长率，评估其与人口统计学、放射学特征、组织病理学变异和增殖指数之间的潜在关联。本研究结果有望确定是否有任何临床或组织病理学特征可提示快速生长的成釉细胞瘤。
由于各种医疗限制或患者因素，在手术干预前有多张X光片的患者被纳入研究。每张X光片的测量包括病变的长度、高度、宽度以及这些维度上的扩展量。此外，在矢状面、冠状面和轴位平面测量病变的周长。通过计算初始X光片与随访X光片测量值的差异，除以两次就诊之间的持续时间来评估放射学特定生长率，以计算每年的生长率。
分析了年龄组、组织病理学变异和Ki-67值之间的特定生长率，在所测量的所有维度上均未发现统计学上的显著相关性。在测量近远中长度时，女性的生长速度在统计学上显著更快（p = 0.04）。在比较放射学特征时，边界不清、严重皮质破坏和牙齿移位的成釉细胞瘤生长速度在统计学上显著更快。
本研究发现与成釉细胞瘤的生长率有显著相关性，特别是在冠状维度上，支持了成釉细胞瘤以颊舌向生长/扩展而闻名的观点。
