Neuvonen P J, Tokola O
Department of Clinical Pharmacology, University of Helsinki, Finland.
Br J Clin Pharmacol. 1987 Dec;24(6):839-41. doi: 10.1111/j.1365-2125.1987.tb03258.x.
The relative bioavailability of carbamazepine mixture was studied after oral and rectal administration to healthy subjects. The absorption was significantly slower after the rectal than after the oral route but the total bioavailability was similar provided the mixture was not defaecated within 2 h of administration. We conclude that carbamazepine can be administered rectally, e.g. to postoperative patients in doses corresponding with oral doses.
对健康受试者口服和直肠给药后，研究了卡马西平混合物的相对生物利用度。直肠给药后吸收明显比口服给药慢，但如果给药后2小时内混合物未排出，则总生物利用度相似。我们得出结论，卡马西平可以直肠给药，例如给术后患者使用与口服剂量相当的剂量。
