内镜下切除鼻后孔息肉后局部应用丝裂霉素C
Topical mitomycin C application post endoscopic removal of antrochoanal polyp.
作者信息
El-Anwar Mohammad Waheed, Elmalt Ashraf, Annany Ahmed, Ahmed Wael A, Nofal Ahmed Abdel Fattah
机构信息
Otorhinolaryngology Head and Neck Surgery Department, Faculty of Medicine Zagazig University Zagazig Egypt.
Otorhinolaryngology Head and Neck Surgery Department, Faculty of Medicine Sohag University Sohag Egypt.
出版信息
Laryngoscope Investig Otolaryngol. 2021 Jun 28;6(4):619-622. doi: 10.1002/lio2.598. eCollection 2021 Aug.
OBJECTIVE
Assessment the effect of topical application of mitomycin-C (MMC) after endoscopic removal of antrochoanal polyp (ACP) on its recurrence rate.
METHODS
This prospective study was done on patients with ACP. Endoscopic nasal surgery has been done to remove the polyp after wide middle meatal antrostomy. The patients were categorized into two groups. In MMC group, after endoscopic ACP removal, MMC on a piece of cotton was topically applied inside the maxillary antrum in the suspected site of ACP origin. A second group was used as a control group without MMC application.
RESULTS
The study included on 40 patients; 20 patients in each group. Topical MMA application was easily performed. No granulation, crust, infection, or bleeding was reported in all cases of both groups. Recurrent polyp was not reported in MMC group, while recurrent polyp was detected in four cases (20%) in control group without MMA application with statistically significant difference ( = .035).
CONCLUSION
Topical MMC application inside the maxillary sinus after endoscopic removal of the ACP is safe, easy, and effective.
LEVEL OF EVIDENCE
2c.
目的
评估内镜下切除上颌窦后鼻孔息肉（ACP）后局部应用丝裂霉素-C（MMC）对其复发率的影响。
方法
对ACP患者进行这项前瞻性研究。在广泛的中鼻道上颌窦造口术后，通过内镜鼻手术切除息肉。将患者分为两组。在MMC组中，内镜下切除ACP后，将浸有MMC的棉片局部应用于上颌窦内疑似ACP起源的部位。第二组作为未应用MMC的对照组。
结果
该研究纳入40例患者，每组20例。局部应用MMC操作简便。两组所有病例均未报告有肉芽、结痂、感染或出血。MMC组未报告复发性息肉，而未应用MMC的对照组有4例（20%）检测到复发性息肉，差异有统计学意义（P = 0.035）。
结论
内镜下切除ACP后在上颌窦内局部应用MMC是安全、简便且有效的。
证据级别
2c。
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