Sperber E F, Wong B Y, Wurpel J N, Moshé S L
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
Brain Res. 1987 Dec 15;465(1-2):243-50. doi: 10.1016/0165-3806(87)90245-8.
The substantia nigra (SN) appears to be a crucial site involved in the modification of seizures. The aim of this study was to elucidate the role of the GABA nigral system in the expression of seizures by comparing the effects of multiple doses of a GABA agonist (muscimol) and a GABA antagonist (bicuculline methobromide) on the development of flurothyl seizures in 16-day-old rat pups. The drugs were infused bilaterally either in the SN or dorsal to the SN. An additional group of pups were infused with bicuculline in the corpus striatum. Results indicate that both drugs facilitated the development of seizures in a dose-related manner when infused into the SN. Infusions of muscimol dorsal to the SN had no effect on seizure latencies while infusions of bicuculline dorsal to SN or corpus striatum still increased the susceptibility of rat pups to seizures. The data suggest that only the effects of muscimol on seizures are specific for the SN and that early in life muscimol may exert its proconvulsant effects via a different receptor site or mechanism than bicuculline.
黑质似乎是参与癫痫发作调节的关键部位。本研究的目的是通过比较多剂量的γ-氨基丁酸（GABA）激动剂（蝇蕈醇）和GABA拮抗剂（甲溴东莨菪碱）对16日龄幼鼠氟烷惊厥发作发展的影响，来阐明黑质GABA能系统在癫痫发作表达中的作用。药物双侧注入黑质或黑质背侧。另一组幼鼠在纹状体中注入东莨菪碱。结果表明，当注入黑质时，两种药物均以剂量相关的方式促进惊厥发作的发展。在黑质背侧注入蝇蕈醇对惊厥潜伏期没有影响，而在黑质背侧或纹状体中注入东莨菪碱仍会增加幼鼠对惊厥的易感性。数据表明，只有蝇蕈醇对惊厥的影响对黑质具有特异性，并且在生命早期，蝇蕈醇可能通过与东莨菪碱不同的受体位点或机制发挥其促惊厥作用。
