Moshé S L, Albala B J
Brain Res. 1984 Apr;315(2):305-8. doi: 10.1016/0165-3806(84)90165-2.
Since recent data utilizing GABAergic stimulation of the substantia nigra (SN) suggest that the SN is a crucial site in a circuitry involved in the modification of seizures in adult rats, the role of the SN was investigated in seizures of rat pups. Bilateral nigral infusions of the GABA agonist muscimol partially protected adult rats against flurothyl-induced seizures, while similar infusions actually facilitated the development of flurothyl seizures in 15-day-old rat pups. These results suggest that age-related differences in the nigral GABA sensitive system may account for the increased susceptibility to generalized seizures of the developing brain.
由于最近利用对黑质（SN）进行GABA能刺激的数据表明，黑质是成年大鼠癫痫发作改变相关神经回路中的关键部位，因此研究了黑质在幼鼠癫痫发作中的作用。向双侧黑质注入GABA激动剂蝇蕈醇可部分保护成年大鼠免受氟烷诱发的癫痫发作，而类似的注入实际上促进了15日龄幼鼠氟烷癫痫发作的发展。这些结果表明，黑质GABA敏感系统中与年龄相关的差异可能是发育中大脑对全身性癫痫发作易感性增加的原因。
