Prasad R, Olson W H
Department of Nuclear Medicine, Long Beach Community Hospital, CA 90804.
Cancer. 1987 Nov 1;60(9):2205-7. doi: 10.1002/1097-0142(19871101)60:9<2205::aid-cncr2820600916>3.0.co;2-k.
If bone biopsies are performed after the sites are located under radionuclide guidance, the chances of sampling the pathologic tissue are greatly improved. After bone scanning, two to three areas for biopsy are chosen and locating is done with 0.05 ml of Tc-99m in a tuberculin syringe under an Anger camera. Methylene blue-xylocaine is injected into the skin up to the periosteum for marking the site of the biopsy. Using this technique, 27 biopsies in 20 patients have been performed (four were open and 23 were closed needle). Pathology was found in 25 biopsies (92.6%), cancer in 22 (81.5%), benign lesions in three (11.1%), and normal bone in two (7.4%).
如果在放射性核素引导下确定部位后进行骨活检，获取病理组织的几率将大大提高。骨扫描后，选择两到三个活检部位，在安格相机下用结核菌素注射器抽取0.05毫升锝-99m进行定位。将亚甲蓝-利多卡因注射到皮肤直至骨膜，以标记活检部位。采用这种技术，对20例患者进行了27次活检（4次为切开活检，23次为闭合针吸活检）。25次活检发现病理改变（92.6%），其中癌症22例（81.5%），良性病变3例（11.1%），正常骨2例（7.4%）。
