Bhutia Sujit Kumar
Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela, 769008, India.
J Nutr Biochem. 2022 Jan;99:108841. doi: 10.1016/j.jnutbio.2021.108841. Epub 2021 Aug 14.
Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and epidemiological evidence establishes an association between vitamin D deficiency and various human diseases. Here, the role of autophagy, the cellular self-degradation process, in vitamin D-dependent function is documented in different cellular settings and discussed the molecular aspects for treating chronic inflammatory, infectious diseases, and cancer. Vitamin D activates autophagy through a genomic and non-genomic signaling pathway to influence a wide variety of physiological functions of different body organs along with bone health and calcium metabolism. Moreover, it induces autophagy as a protective mechanism to inhibit oxidative stress and apoptosis to regulate cell proliferation, differentiation, and immune modulation. Furthermore, vitamin D and its receptor regulate autophagy signaling to control inflammation and host immunity by activating antimicrobial defense mechanisms. Vitamin D has been revealed as a potent anticancer agent and induces autophagy to increase the response to radiation and chemotherapeutic drugs for potential cancer therapy. Increasing vitamin D levels in the human body through timely exposure to sunlight or vitamin D supplements could activate autophagy as part of the homeostasis mechanism to prevent multiple human diseases and aging-associated dysfunctions.
维生素D调节多效性作用以维持细胞内稳态，流行病学证据表明维生素D缺乏与多种人类疾病之间存在关联。在此，自噬（细胞自我降解过程）在维生素D依赖性功能中的作用在不同细胞环境中得到了记录，并讨论了其在治疗慢性炎症、传染病和癌症方面的分子机制。维生素D通过基因组和非基因组信号通路激活自噬，以影响不同身体器官的多种生理功能，以及骨骼健康和钙代谢。此外，它诱导自噬作为一种保护机制，以抑制氧化应激和细胞凋亡，从而调节细胞增殖、分化和免疫调节。此外，维生素D及其受体通过激活抗菌防御机制来调节自噬信号，以控制炎症和宿主免疫。维生素D已被证明是一种有效的抗癌剂，并诱导自噬以增强对辐射和化疗药物的反应，从而用于潜在的癌症治疗。通过及时晒太阳或补充维生素D来提高人体维生素D水平，可以激活自噬作为稳态机制的一部分，以预防多种人类疾病和与衰老相关的功能障碍。
