Kojecký Vladimír
Vnitr Lek. 2015 Jul-Aug;61(7-8):695-7.
Receptors for vitamin D are present almost in all body tissues. Vitamin D does not only act as a regulator of calcium and phosphorus metabolism, but also a substance which modulates the immunity system function, regulates cell proliferation. Genetic, epidemiological and experimental data indicate a possible role of vitamin D deficiency in the development of some diseases, mainly of autoimmune diseases and tumours. The benefit of curative intake of vitamin D has so far not been proven. There is no reason why the deficiency of vitamin D should not be covered. The substitution should start with the replenishment of the lacking amount of vitamin D (which may even be several hundred thousand units) and involve ongoing intake of the recommended substitution dose of 800-1000 vitamin D units per day.
维生素D受体几乎存在于人体所有组织中。维生素D不仅是钙和磷代谢的调节剂,还是一种调节免疫系统功能、调控细胞增殖的物质。遗传学、流行病学和实验数据表明,维生素D缺乏可能在某些疾病(主要是自身免疫性疾病和肿瘤)的发生发展中起作用。目前尚未证实治疗性摄入维生素D的益处。没有理由不弥补维生素D的缺乏。补充应从补充缺乏的维生素D量(甚至可能是几十万单位)开始,并持续每日摄入推荐的替代剂量800 - 1000维生素D单位。