Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Oncology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Gene. 2021 Dec 15;804:145901. doi: 10.1016/j.gene.2021.145901. Epub 2021 Aug 14.
Numerous epidemiological studies have been published to elucidate the potential associations of IL-17A -197G/A (rs2275913) and IL-17F 7488T/C (rs763780) with cancer risk in Asians. Nevertheless, the results from different studies remain controversial. To identify the roles of the two polymorphisms in cancer risk, we performed this current meta-analysis.
The available literature was derived from five databases, covering relevant articles updated through February 17, 2021. Five different analysis models with corresponding odds ratios (ORs) and 95% confidence intervals (CIs) were applied to appraise the gene-disease correlation.
In total, 43 case-control studies with 31,237 subjects were enrolled. Overall analyses indicated that there was significantly increased cancer risk led by IL-17A -197G/A under the five analysis models. A similar tendency was also identified in the subgroup analysis of cancer type, especially for gastric cancer, cervical cancer, colorectal cancer, and oral carcinoma. As for IL-17F 7488T/C, we revealed that patients who carried this variant had a higher cancer risk in the recessive model among the overall analyses, as well as subgroup analyses of cervical cancer or oral carcinoma.
In summary, our work confirmed that IL-17A -197G/A acted as a risk factor for diverse cancer types and that IL-17F 7488T/C might be involved in cervical cancer and oral carcinoma.
许多流行病学研究已经发表，以阐明 IL-17A-197G/A(rs2275913)和 IL-17F7488T/C(rs763780)与亚洲人群癌症风险的潜在关联。然而，来自不同研究的结果仍存在争议。为了确定这两种多态性在癌症风险中的作用，我们进行了本次荟萃分析。
从五个数据库中获取了现有文献，涵盖了截至 2021 年 2 月 17 日更新的相关文章。应用了五种不同的分析模型，相应的比值比(OR)和 95%置信区间(CI)用于评估基因-疾病相关性。
共纳入了 43 项病例对照研究，共 31237 例患者。总体分析表明，在五种分析模型中，IL-17A-197G/A 导致癌症风险显著增加。在癌症类型的亚组分析中也发现了类似的趋势，特别是胃癌、宫颈癌、结直肠癌和口腔癌。对于 IL-17F7488T/C，我们发现，在总体分析以及宫颈癌或口腔癌的亚组分析中，携带该变异的患者在隐性模型中癌症风险更高。
总之，我们的工作证实，IL-17A-197G/A 是多种癌症类型的危险因素，而 IL-17F7488T/C 可能与宫颈癌和口腔癌有关。
